MEMSDUKEPRATT School of engineering

Education

  • PhD, Columbia University, 1993
  • BS, Princeton University, 1984
Lori A Setton
  • Office Location: 355A, Med Sci Res Building
  • Email Address: setton@duke.edu

    • Research in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus. Work in the Laboratory is focused on material characterization of native and healing biological tissues as well as tissue engineered biomaterial constructs. Studies combining engineering and biology are also used to determine the role of mechanical factors to promote and control healing of cartilaginous tissues. Research in the Laboratory is funded by The National Institutes of Health, The National Science Foundation, The Office of Naval Research, The Whitaker Foundation, and The North Carolina Biotechnology Center.

    Specialties
    Tissue Repair, Engineering
    Biological Materials

    TEACHING (Spring 2010)

    BME 230.01, TISSUE BIOMECHANICS,

    Recent Publications More Publications

    1. Gilchrist, Christopher L. and Witvoet-Braam, Sietske W. and Guilak, Farshid and Setton, Lori A., Measurement of intracellular strain on deformable substrates with texture correlation, Journal of Biomechanics, vol. 40 no. 4 (2007), ppt. 786 - 794 , [013] [abs]
    2. Li Cao and Youn, I. and Guilak, F. and Setton, L.A., Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model, Trans. ASME, J. Biomech. Eng. (USA), vol. 128 no. 5 (2006), ppt. 766 - 71 , [1.2246237] [abs]
    3. Betre, Helawe and Liu, Wenge and Zalutsky, Michael R. and Chilkoti, Ashutosh and Kraus, Virginia B. and Setton, Lori A., A thermally responsive biopolymer for intra-articular drug delivery, Journal of Controlled Release, vol. 115 no. 2 (2006), ppt. 175 - 182 , [022] [abs]
    4. Setton, L.A. and Ong, S.R. and Trabbic-Carlson, K.A. and Nettles, D.L. and Lim, D.W. and Chilkoti, A., Epitope tagging for tracking elastin-like polypeptides, Biomaterials (UK), vol. 27 no. 9 (2006), ppt. 1930 - 5 , [018] [abs]
    5. Setton, L.A. and Betre, H. and Ong, S.R. and Guilak, F. and Chilkoti, A. and Fermor, B., Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide, Biomaterials (UK), vol. 27 no. 1 (2006), ppt. 91 - 9 , [071] [abs]
    6. Boyd, L.M. and Richardson, W.J. and Chen, J. and Kraus, V.B. and Tewari, A. and Setton, L.A., Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR, Ann. Biomed. Eng. (USA), vol. 33 no. 8 (2005), ppt. 1071 - 7 , [s10439-005-5775-y] [abs]
    7. Gilchrist, C.L. and Xia, J.Q. and Setton, L.A. and Hsu, E.W., High-resolution determination of soft tissue deformations using MRI and first-order texture correlation, IEEE Trans. Med. Imaging (USA), vol. 23 no. 5 (2004), ppt. 546 - 53 , [TMI.2004.825616] [abs]
    8. Nettles, D.L. and Vail, T.P. and Morgan, M.T. and Grinstaff, M.W. and Setton, L.A., Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair, Ann. Biomed. Eng. (USA), vol. 32 no. 3 (2004), ppt. 391 - 7 , [94] [abs]
    9. Upton, Maureen L. and Chen, Jun and Guilak, Farshid and Setton, Lori A., Differential effects of static and dynamic compression on meniscal cell gene expression, Journal of Orthopaedic Research, vol. 21 no. 6 (2003), ppt. 963 - 969 , [S0736-0266(03)00063-9] [abs]
    10. Baer, A.E. and Laursen, T.A. and Guilak, F. and Setton, L.A., The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model, Trans. ASME, J. Biomech. Eng. (USA), vol. 125 no. 1 (2003), ppt. 1 - 11 , [1.1532790] [abs]

    The mission of Duke's Mechanical Engineering and Materials Science educational programs is to provide the knowledge, skills, and credentials needed to be successful in the practice of engineering; the preparation necessary to undertake professional registration; an educational preparation for graduate or professional study; and an education background that is the basis for professional growth and leadership throughout a career that may encompass a broad range of endeavors, both technical and non-technical.