My research is in the field of dynamic systems, measurement and control, and my group's current focus is aimed at the development of new instruments for the exploration of single-molecule mechanics and for the deposition and control of materials at the nanoscale, required to enable an industry in bio-nano-manufacturing. This includes recent projects devoted to the study of multi-valency in molecular binding events and the use of enzymatic stamps to render surface patterning as an alternative to micro-contact printing. Our group continues to serve as a resource within the Center for Biologically Inspired Materials and Material Systems with respect to the development and advancement of new instrumentation and signal processing tools. Our most recent research activity devoted to quantitative assays, obtained through the detection of single molecule binding events was published in PNAS.

Recent Publications More Publications

1. K. D. Wulff and D. G. Cole and R. L. Clark, An adaptive system identification approach to optical trap calibration, Optics Express, vol. 16 no. 7 (2008), ppt. 4420 -- 4425
   
2. Y. Q. Wu and M. S. Johannes and R. L. Clark, AFM-based voltage assisted nanoelectro spinning, Materials Letters, vol. 62 no. 4-5 (2008), ppt. 699 -- 702
   
3. Cox, D.E., G. P. Gibs, R.L. Clark, and J.S. Vipperman, Experimental Robust Control of Structural Acoustic Control, ASME Journal of Vibration and Acoustics, vol. 121 no. 4 (2008), ppt. 433-440
   
4. Ma, H., M. Textor, R.L. Clark and A. Chilkoti, Real time monitoring of surface initiated atom transfer radical polymerization by quartz crystal microbalance with dissipation, Biointerphases, vol. 1 no. 35-39 (2008)
   
5. Chow, D.C., M.S. Johannes, W. Lee, R.L. Clark, S. Zauscher and A. Chilkoti, Nanofabrication with biomolecules, Materials Today, vol. 8 no. Suppl 1 (2008), ppt. 30-39