MEMSDUKEPRATT School of engineering

Education

  • PhD, University of Pennsylvania, 1987
  • Postdoc, Massachusetts Institute of Technology (MIT), 1985
  • BS, University of California, 1977
Kam W Leong
  • Office Location: 1395 CIEMAS
  • Office Phone: (919) 660-8466
  • Email Address: kam.leong@duke.edu

    • Professor Leong's research interest focuses on biomaterials design, particularly for synthesis of nanoparticles for gene and immunotherapy, and nanofibers for regenerative medicine applications.

    Biomaterials Design:

    • design of self-assembled fibers for tissue engineering
    • synthesis of new biodegradable polymers and new polyelectrolytes for drug and gene delivery applied to tissue engineering
    • synthesis of thermosensitive hydrogels for tissue engineering

    Controlled Drug and Gene Delivery:

    • oral gene delivery for hemophilia A and B
    • non-viral gene delivery to the GI tract, bladder, and CNS
    • oral delivery of antigen genes for vaccination

    Tissue Engineering:

    • study of interaction of stem cells with biofunctional polymeric surface
    • expansion of hematopoietic stem cells
    • nerve guidance channels with drug and gene delivery functions
    • microencapsulation of stem cells and genetically-engineered cells
    • development of bioartificial nucleus pulposus device
    • study of interaction of SMC and neuronal stem cells with synthetic nanostructured biomaterials

    Specialties
    Biological Materials
    Drug Delivery
    Tissue Repair, Tissue Engineering

    TEACHING (Spring 2010)

    BME 265.03, BIOMEDICAL POLYMERS,

    Recent Publications More Publications

    1. T. W. Prow and I. Bhutto and S. Y. Kim and R. Grebe and C. Merges and D. S. Mcleod and K. Uno and M. Mennon and L. Rodriguez and K. Leong and G. A. Lutty, Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium, Nanomedicine-nanotechnology Biology And Medicine, vol. 4 no. 4 (2008), ppt. 340 -- 349 [abs]
    2. N. Bursac and Y. H. Loo and K. Leong and L. Tung, Novel anisotropic engineered cardiac tissues: Studies of electrical propagation, Biochemical And Biophysical Research Communications, vol. 361 no. 4 (2007), ppt. 847 -- 853 [abs]
    3. Chen, Beiyi and Dang, Jiyoung and Tan, Tuan Lin and Fang, Ning and Chen, Wei Ning and Leong, Kam W. and Chan, Vincent, Dynamics of smooth muscle cell deadhesion from thermosensitive hydroxybutyl chitosan, Biomaterials, vol. 28 no. 8 (2007), ppt. 1503 - 1514 , [027] [abs]
    4. Zhang, Yue and Chai, Chou and Jiang, Xue Song and Teoh, Swee Hin and Leong, Kam W., Fibronectin immobilized by covalent conjugation or physical adsorption shows different bioactivity on aminated-PET, Materials Science and Engineering C, vol. 27 no. 2 (2007), ppt. 213 - 219 , [013] [abs]
    5. Yim, Evelyn K.F. and Liao, I-Chien and Leong, Kam W., Tissue compatibility of interfacial polyelectrolyte complexation fibrous scaffold: Evaluation of blood compatibility and biocompatibility, Tissue Engineering, vol. 13 no. 2 (2007), ppt. 423 - 433 , [0113] [abs]

    Research Interests

      Leong's research interest focuses on biomaterials design, particularly for synthesis of nanoparticles for gene and immunotherapy, and nanofibers for regenerative medicine applications.

    The mission of Duke's Mechanical Engineering and Materials Science educational programs is to provide the knowledge, skills, and credentials needed to be successful in the practice of engineering; the preparation necessary to undertake professional registration; an educational preparation for graduate or professional study; and an education background that is the basis for professional growth and leadership throughout a career that may encompass a broad range of endeavors, both technical and non-technical.