Pei Zhong

Image of Pei Zhong

Anderson-Rupp Professor of Mechanical Engineering and Materials Science

My research focuses on four broad and interconnected areas in the emerging field of therapeutic ultrasound, which is located at the interface of engineering, biology and clinical medicine. Current research interests in my group include:

  1. Ultrasound-targeted gene delivery and activation
  2. Synergistic combination of high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment
  3. Innovations in shock wave lithotripsy (SWL) technology
  4. Mechanics and bioeffects of acoustic cavitation.

We are taking an integrated and translational approach that combines fundamental research with engineering and applied technology development to devise novel and enabling ultrasonic techniques for a variety of clinical applications. Our fundamental research focuses on achieving a mechanistic understanding of the stress response of biological cells and tissues induced by ultrasound exposure. Based on this knowledge, we develop better instrumentation and treatment strategies for ultrasound-targeted gene delivery and activation in internal organs, for improving the overall efficacy of HIFU therapy for breast and prostate cancers, and for SWL treatment of renal calculi. A long-standing research effort in my laboratory is to understand the dynamics and biological consequences of the interaction of optically or acoustically generated cavitation bubble(s) with shock waves near a boundary or in constrained media. We employ a diverse range of experimental techniques including high-speed Schlieren and photoelastic imaging, pressure measurement via fiber optical probe hydrophone, as well as cell, phantom and animal models. Our research activities are primarily supported by NIH and through collaborations with the medical device industry.

Appointments and Affiliations
  • Anderson-Rupp Professor of Mechanical Engineering and Materials Science
  • Professor in the Department of Mechanical Enginnering and Materials Science
Contact Information:
  • Office Location: 1103 Engineering Annex, Durham, NC 27708
  • Office Phone: (919) 660-5336
  • Email Address: pzhong@duke.edu
Education:

  • Ph.D. University of Texas at Dallas, 1992
  • M.S. Univ Texas Arlington, 1988

Research Interests:

Ultrasound-targeted gene delivery and activation; Synergistic combination of high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment; Innovations in shock wave lithotripsy (SWL) technology; and Mechanics and bioeffects of acoustic cavitation.

Specialties:

Acoustics
Lithotripsy
Fluid Mechanics
Medical Instrumentation
Cancer Diagnostics and Therapy

Awards, Honors, and Distinctions:

  • Searle New Investigator Research Award, American Foundation for Urological Disease, 1994-1996
  • Young Investigator Award, VIII International Symposium on Urolithiasis, 1996

Courses Taught:
  • ME 336L: Fluid Mechanics
  • ME 394: Engineering Undergraduate Fellows Projects
  • ME 491: Special Projects in Mechanical Engineering
  • ME 492: Special Projects in Mechanical Engineering
  • ME 493: Engineering Undergraduate Fellows Projects
  • ME 494: Engineering Undergraduate Fellows Projects
  • ME 555: Advanced Topics in Mechanical Engineering
  • ME 759: Special Readings in Mechanical Engineering

Representative Publications: (More Publications)
    • Neisius, A; Smith, NB; Sankin, G; Kuntz, NJ; Madden, JF; Fovargue, DE; Mitran, S; Lipkin, ME; Simmons, WN; Preminger, GM; Zhong, P, Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter., Proceedings of the National Academy of Sciences of USA, vol 111 no. 13 (2014), pp. E1167-E1175 [10.1073/pnas.1319203111] [abs].
    • Smith, NB; Zhong, P, A heuristic model of stone comminution in shock wave lithotripsy., Journal of the Acoustical Society of America, vol 134 no. 2 (2013), pp. 1548-1558 [10.1121/1.4812876] [abs].
    • Lautz, J; Sankin, G; Zhong, P, Turbulent water coupling in shock wave lithotripsy., Physics in Medicine and Biology, vol 58 no. 3 (2013), pp. 735-748 [10.1088/0031-9155/58/3/735] [abs].
    • Hsiao, C-T; Choi, J-K; Singh, S; Chahine, GL; Hay, TA; Ilinskii, YA; Zabolotskaya, EA; Hamilton, MF; Sankin, G; Yuan, F; Zhong, P, Modelling single- and tandem-bubble dynamics between two parallel plates for biomedical applications, Journal of Fluid Mechanics, vol 716 (2013), pp. 137-170 [10.1017/jfm.2012.526] [abs].
    • Smith, N; Zhong, P, Stone comminution correlates with the average peak pressure incident on a stone during shock wave lithotripsy., Journal of Biomechanics, vol 45 no. 15 (2012), pp. 2520-2525 [10.1016/j.jbiomech.2012.07.025] [abs].
    • Sankin, GN; Piech, D; Zhong, P, Stereoscopic high-speed imaging using additive colors., Review of Scientific Instruments, vol 83 no. 4 (2012) [10.1063/1.3697747] [abs].
    • Huang, X; Yuan, F; Liang, M; Lo, HW; Shinohara, ML; Robertson, C; Zhong, P, M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer., PLoS One, vol 7 no. 7 (2012) [10.1371/journal.pone.0041632] [abs].
    • Yuan, F; Sankin, G; Zhong, P, Dynamics of tandem bubble interaction in a microfluidic channel., Journal of the Acoustical Society of America, vol 130 no. 5 (2011), pp. 3339-3346 [10.1121/1.3626134] [abs].
    • Lautz, J; Sankin, G; Yuan, F; Zhong, P, Displacement of particles in microfluidics by laser-generated tandem bubbles., Applied Physics Letters, vol 97 no. 18 (2010) [10.1063/1.3511538] [abs].
    • Sankin, GN; Yuan, F; Zhong, P, Pulsating tandem microbubble for localized and directional single-cell membrane poration., Physical Review Letters, vol 105 no. 7 (2010) [abs].
    • Qin, J; Simmons, WN; Sankin, G; Zhong, P, Effect of lithotripter focal width on stone comminution in shock wave lithotripsy., Journal of the Acoustical Society of America, vol 127 no. 4 (2010), pp. 2635-2645 [10.1121/1.3308409] [abs].
    • Iloreta, JI; Zhou, Y; Sankin, GN; Zhong, P; Szeri, AJ, Assessment of shock wave lithotripters via cavitation potential., Physics of Fluids, vol 19 no. 8 (2007) [10.1063/1.2760279] [abs].
    • Klaseboer, E; Fong, SW; Turangan, CK; Khoo, BC; Szeri, AJ; Calvisi, ML; Sankin, GN; Zhong, P, Interaction of lithotripter shockwaves with single inertial cavitation bubbles., Journal of Fluid Mechanics, vol 593 (2007), pp. 33-56 [10.1017/S002211200700852X] [abs].
    • Hu, Z; Yang, XY; Liu, Y; Sankin, GN; Pua, EC; Morse, MA; Lyerly, HK; Clay, TM; Zhong, P, Investigation of HIFU-induced anti-tumor immunity in a murine tumor model., Journal of Translational Medicine, vol 5 (2007) [10.1186/1479-5876-5-34] [abs].
    • Liu, Y; Kon, T; Li, C; Zhong, P, High intensity focused ultrasound-induced gene activation in solid tumors., Journal of the Acoustical Society of America, vol 120 no. 1 (2006), pp. 492-501 [abs].
    • Sankin, GN; Zhong, P, Interaction between shock wave and single inertial bubbles near an elastic boundary, Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, vol 74 no. 4 (2006) [10.1103/PhysRevE.74.046304] [abs].
    • Sankin, GN; Simmons, WN; Zhu, SL; Zhong, P, Shock wave interaction with laser-generated single bubbles., Physical Review Letters, vol 95 no. 3 (2005) [abs].
    • Chen, WS; Lu, XC; Liu, YB; Zhong, P, The effect of surface agitation on ultrasound-mediated gene transfer in vitro, Journal of the Acoustical Society of America, vol 116 no. 4 (2004), pp. 2440-2450 [10.1121/1.1777855] [abs].
    • Zhu, S; Cocks, FH; Preminger, GM; Zhong, P, The role of stress waves and cavitation in stone comminution in shock wave lithotripsy., Ultrasound in Medicine and Biology, vol 28 no. 5 (2002), pp. 661-671 [abs].
    • Zhong, P; Zhou, Y, Suppression of large intraluminal bubble expansion in shock wave lithotripsy without compromising stone comminution: methodology and in vitro experiments., Journal of the Acoustical Society of America, vol 110 no. 6 (2001), pp. 3283-3291 [abs].
    • Xi, X; Zhong, P, Dynamic photoelastic study of the transient stress field in solids during shock wave lithotripsy., Journal of the Acoustical Society of America, vol 109 no. 3 (2001), pp. 1226-1239 [abs].
    • Zhong, P; Zhou, Y; Zhu, S, Dynamics of bubble oscillation in constrained media and mechanisms of vessel rupture in SWL., Ultrasound in Medicine and Biology, vol 27 no. 1 (2001), pp. 119-134 [abs].
    • Zhu, S; Kourambas, J; Munver, R; Preminger, GM; Zhong, P, Quantification of the tip movement of lithotripsy flexible pneumatic probes., Journal of Urology, vol 164 no. 5 (2000), pp. 1735-1739 [abs].
    • Heimbach, D; Munver, R; Zhong, P; Jacobs, J; Hesse, A; Müller, SC; Preminger, GM, Acoustic and mechanical properties of artificial stones in comparison to natural kidney stones., Journal of Urology, vol 164 no. 2 (2000), pp. 537-544 [abs].
    • Xi, X; Zhong, P, Improvement of stone fragmentation during shock-wave lithotripsy using a combined EH/PEAA shock-wave generator-in vitro experiments., Ultrasound in Medicine and Biology, vol 26 no. 3 (2000), pp. 457-467 [abs].
    • Zhong, P; Lin, H; Xi, X; Zhu, S; Bhogte, ES, Shock wave-inertial microbubble interaction: methodology, physical characterization, and bioeffect study., Journal of the Acoustical Society of America, vol 105 no. 3 (1999), pp. 1997-2009 [abs].
    • Zhong, P; Cioanta, I; Cocks, FH; Preminger, GM, Inertial cavitation and associated acoustic emission produced during electrohydraulic shock wave lithotripsy, Journal of the Acoustical Society of America, vol 101 no. 5 I (1997), pp. 2940-2950 [10.1121/1.418522] [abs].
    • Zhong, P; Preminger, GM, Mechanisms of differing stone fragility in extracorporeal shockwave lithotripsy., Journal of Endourology, vol 8 no. 4 (1994), pp. 263-268 [abs].
    • Zhong, P; Chuong, CJ; Preminger, GM, Propagation of shock waves in elastic solids caused by cavitation microjet impact. II: Application in extracorporeal shock wave lithotripsy., Journal of the Acoustical Society of America, vol 94 no. 1 (1993), pp. 29-36 [abs].
    • Zhong, P; Chuong, CJ, Propagation of shock waves in elastic solids caused by cavitation microjet impact. I: Theoretical formulation., Journal of the Acoustical Society of America, vol 94 no. 1 (1993), pp. 19-28 [abs].
    • Zhong, P; Chuong, CJ; Preminger, GM, Characterization of fracture toughness of renal calculi using a microindentation technique, Journal of Materials Science Letters, vol 12 no. 18 (1993), pp. 1460-1462 [abs].