Anderson-Rupp Professor of Mechanical Engineering and Materials Science
My research focuses on four broad and interconnected areas in the emerging field of therapeutic ultrasound, which is located at the interface of engineering, biology and clinical medicine. Current research interests in my group include:
- Ultrasound-targeted gene delivery and activation
- Synergistic combination of high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment
- Innovations in shock wave lithotripsy (SWL) technology
- Mechanics and bioeffects of acoustic cavitation.
We are taking an integrated and translational approach that combines fundamental research with engineering and applied technology development to devise novel and enabling ultrasonic techniques for a variety of clinical applications. Our fundamental research focuses on achieving a mechanistic understanding of the stress response of biological cells and tissues induced by ultrasound exposure. Based on this knowledge, we develop better instrumentation and treatment strategies for ultrasound-targeted gene delivery and activation in internal organs, for improving the overall efficacy of HIFU therapy for breast and prostate cancers, and for SWL treatment of renal calculi. A long-standing research effort in my laboratory is to understand the dynamics and biological consequences of the interaction of optically or acoustically generated cavitation bubble(s) with shock waves near a boundary or in constrained media. We employ a diverse range of experimental techniques including high-speed Schlieren and photoelastic imaging, pressure measurement via fiber optical probe hydrophone, as well as cell, phantom and animal models. Our research activities are primarily supported by NIH and through collaborations with the medical device industry.
Appointments and Affiliations
- Anderson-Rupp Professor of Mechanical Engineering and Materials Science
- Professor in the Department of Mechanical Enginnering and Materials Science
- Office Location: 1103 Engineering Annex, Durham, NC 27708
- Office Phone: (919) 660-5336
- Email Address: email@example.com
- Ph.D. University of Texas at Dallas, 1992
- M.S. Univ Texas Arlington, 1988
Ultrasound-targeted gene delivery and activation; Synergistic combination of high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment; Innovations in shock wave lithotripsy (SWL) technology; and Mechanics and bioeffects of acoustic cavitation.
Cancer Diagnostics and Therapy
Awards, Honors, and Distinctions:
- Searle New Investigator Research Award, American Foundation for Urological Disease
- Young Investigator Award, VIII International Symposium on Urolithiasis
- ME 336L: Fluid Mechanics
- ME 394: Engineering Undergraduate Fellows Projects
- ME 491: Special Projects in Mechanical Engineering
- ME 492: Special Projects in Mechanical Engineering
- ME 493: Engineering Undergraduate Fellows Projects
- ME 494: Engineering Undergraduate Fellows Projects
- ME 555: Advanced Topics in Mechanical Engineering
Representative Publications: (More Publications)
- Mancini, JG; Neisius, A; Smith, N; Sankin, G; Astroza, GM; Lipkin, ME; Simmons, WN; Preminger, GM; Zhong, P, Assessment of a modified acoustic lens for electromagnetic shock wave lithotripters in a swine model., Journal of Urology, vol 190 no. 3 (2013), pp. 1096-1101 [10.1016/j.juro.2013.02.074] [abs].
- Fovargue, DE; Mitran, S; Smith, NB; Sankin, GN; Simmons, WN; Zhong, P, Experimentally validated multiphysics computational model of focusing and shock wave formation in an electromagnetic lithotripter., Journal of the Acoustical Society of America, vol 134 no. 2 (2013), pp. 1598-1609 [10.1121/1.4812881] [abs].
- Smith, NB; Zhong, P, A heuristic model of stone comminution in shock wave lithotripsy., Journal of the Acoustical Society of America, vol 134 no. 2 (2013), pp. 1548-1558 [10.1121/1.4812876] [abs].
- Lautz, J; Sankin, G; Zhong, P, Turbulent water coupling in shock wave lithotripsy., Physics in Medicine and Biology, vol 58 no. 3 (2013), pp. 735-748 [10.1088/0031-9155/58/3/735] [abs].
- Hsiao, C-T; Choi, J-K; Singh, S; Chahine, GL; Hay, TA; Ilinskii, YA; Zabolotskaya, EA; Hamilton, MF; Sankin, G; Yuan, F; Zhong, P, Modelling single- and tandem-bubble dynamics between two parallel plates for biomedical applications, Journal of Fluid Mechanics, vol 716 (2013), pp. 137-170 [10.1017/jfm.2012.526] [abs].