Lori A. Setton

Image of Lori A. Setton

William Bevan Professor of Biomedical Engineering

Research in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus. Work in the Laboratory is focused on engineering and evaluating materials for tissue regeneration and drug delivery. Studies combining engineering and biology are also used to determine the role of mechanical factors to promote and control healing of cartilaginous tissues. Research in the Laboratory is funded by The National Institutes of Health, The Coulter Foundation and The North Carolina Biotechnology Center.

Appointments and Affiliations
  • William Bevan Professor of Biomedical Engineering
  • Bass Fellow
  • Professor of Biomedical Engineering
Contact Information:

  • Ph.D. Columbia University, 1993
  • B.S.E. Princeton University, 1984

Curriculum Vitae

Tissue Repair, Engineering
Biological Materials

Awards, Honors, and Distinctions:

  • Dean's Award for Excellence in Mentoring, Duke University, Graduate School, 2004
  • Fellow, American Institute of Biological and Medical Engineers, 2005
  • Van C. Mow Medal, American Society of Mechanical Engineers, 2007

Courses Taught:
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 530: Introduction to Tissue Biomechanics (GE, BB)
  • BME 530: Tissue Biomechanics (GE, BB)
  • BME 791: Graduate Independent Study
  • BME 899: Special Readings in Biomedical Engineering

Representative Publications: (More Publications)
    • Karikari, IO; Gilchrist, CL; Jing, L; Alcorta, DA; Chen, J; Richardson, WJ; Gabr, MA; Bell, RD; Kelley, MJ; Bagley, CA; Setton, LA, Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines., Journal of Neurosurgery: Spine, vol 21 no. 3 (2014), pp. 386-393 [10.3171/2014.4.spine13262] [abs].
    • Jeong, CG; Francisco, AT; Niu, Z; Mancino, RL; Craig, SL; Setton, LA, Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis., Acta Biomaterialia, vol 10 no. 8 (2014), pp. 3421-3430 [10.1016/j.actbio.2014.05.012] [abs].
    • Francisco, AT; Hwang, PY; Jeong, CG; Jing, L; Chen, J; Setton, LA, Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration., Acta Biomaterialia, vol 10 no. 3 (2014), pp. 1102-1111 [10.1016/j.actbio.2013.11.013] [abs].
    • Bowles, RD; Mata, BA; Bell, RD; Mwangi, TK; Huebner, JL; Kraus, VB; Setton, LA, In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis., Arthritis && Rheumatology, vol 66 no. 3 (2014), pp. 637-646 [10.1002/art.38279] [abs].
    • Hwang, PY; Chen, J; Jing, L; Hoffman, BD; Setton, LA, The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review., Journal of Biomechanical Engineering, vol 136 no. 2 (2014) [10.1115/1.4026360] [abs].