Kam Leong

Image of Kam Leong

James B. Duke Professor of Biomedical Engineering

Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine

Biomaterials Design:

  • design of self-assembled fibers for tissue engineering
  • microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery
  • synthesis of novel quantum dots for biomedical applications

Controlled Drug and Gene Delivery:

  • oral gene delivery for hemophilia A and B
  • non-viral gene delivery to the GI tract
  • oral delivery of antigen genes for vaccination

Tissue Engineering:

  • study of response of stem cells to nanotopographical cues
  • expansion of hematopoietic stem cells
  • nerve guidance channels with drug and gene delivery functions
  • microencapsulation of stem cells and genetically-engineered cells
  • development of bioartificial nucleus pulposus device
  • study of interaction of stem cells with synthetic nanostructured biomaterials

Appointments and Affiliations
  • James B. Duke Professor of Biomedical Engineering
  • Professor of Biomedical Engineering
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in Surgery
  • Member of the Duke Cancer Institute
Contact Information:
Education:

  • Ph.D. University of Pennsylvania, 1987
  • B.S.CH.E. University of California at Santa Barbara, 1977

Curriculum Vitae
Research Interests:

Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine.

Specialties:

Biological Materials
Drug Delivery
Tissue Repair, Tissue Engineering
Biophotonics
Nanoscience

Awards, Honors, and Distinctions:

  • National Academy of Engineering
  • Stansell Family Distinguished Research Award
  • 3M Pharmaceuticals Recognition Award, Controlled Release Society
  • Award for Recognition of Pioneering Contribution in Polymer chemistry and Bioomedical Engineering, Chinese-American Chemical Society
  • Capsugel Award on Innovative Aspects of Controlled Release Research, Controlled Release Society
  • Cygnus Recognition Award, Controlled Release Society
  • Excellence in Guidance of Graduate Student Research, Controlled Release Society
  • Jorge Heller Manuscript Award, Journal of Controlled Release
  • Proctor & Gamble Recognition Award, Controlled Release Society
  • Young Investigator Research Achievement Award, Controlled Release Society

Courses Taught:
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590: Advanced Topics in Biomedical Engineering
  • BME 899: Special Readings in Biomedical Engineering

Representative Publications: (More Publications)
    • Hong, S; Jung, Y; Yen, R; Chan, HF; Leong, KW; Truskey, GA; Zhao, X, Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems., Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering, vol 14 no. 3 (2014), pp. 514-521 [10.1039/c3lc51076j] [abs].
    • Perez-Pinera, P; Kocak, DD; Vockley, CM; Adler, AF; Kabadi, AM; Polstein, LR; Thakore, PI; Glass, KA; Ousterout, DG; Leong, KW; Guilak, F; Crawford, GE; Reddy, TE; Gersbach, CA, RNA-guided gene activation by CRISPR-Cas9-based transcription factors., Nature Methods, vol 10 no. 10 (2013), pp. 973-976 [10.1038/nmeth.2600] [abs].
    • Zhang, Y; Ho, YP; Chiu, YL; Chan, HF; Chlebina, B; Schuhmann, T; You, L; Leong, KW, A programmable microenvironment for cellular studies via microfluidics-generated double emulsions., Biomaterials, vol 34 no. 19 (2013), pp. 4564-4572 [10.1016/j.biomaterials.2013.03.002] [abs].
    • Phua, KK; Leong, KW; Nair, SK, Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format., Journal of Controlled Release, vol 166 no. 3 (2013), pp. 227-233 [10.1016/j.jconrel.2012.12.029] [abs].
    • Peters, EB; Christoforou, N; Leong, KW; Truskey, GA, Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro., Tissue Engineering Part A: Tissue Engineering, vol 19 no. 5-6 (2013), pp. 697-706 [10.1089/ten.tea.2011.0704] [abs].