Kam Leong

Image of Kam Leong

Adjunct Professor of Biomedical Engineering

Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine

Biomaterials Design:

  • design of self-assembled fibers for tissue engineering
  • microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery
  • synthesis of novel quantum dots for biomedical applications

Controlled Drug and Gene Delivery:

  • oral gene delivery for hemophilia A and B
  • non-viral gene delivery to the GI tract
  • oral delivery of antigen genes for vaccination

Tissue Engineering:

  • study of response of stem cells to nanotopographical cues
  • expansion of hematopoietic stem cells
  • nerve guidance channels with drug and gene delivery functions
  • microencapsulation of stem cells and genetically-engineered cells
  • development of bioartificial nucleus pulposus device
  • study of interaction of stem cells with synthetic nanostructured biomaterials

Appointments and Affiliations
  • Adjunct Professor of Biomedical Engineering
Contact Information:
Education:

  • Ph.D. University of Pennsylvania, 1987
  • B.S.CH.E. University of California at Santa Barbara, 1977

Curriculum Vitae
Research Interests:

Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine.

Specialties:

Biological Materials
Drug Delivery
Tissue Repair, Tissue Engineering
Biophotonics
Nanoscience

Courses Taught:
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590: Advanced Topics in Biomedical Engineering
  • BME 899: Special Readings in Biomedical Engineering

Representative Publications: (More Publications)
    • Ho, Y. P. and Leong, K. W., Quantum dot-based theranostics, Nanoscale, vol 2 no. 1 (2010), pp. 60-68 [abs].
    • Yim, E. K. F. and Darling, E. M. and Kulangara, K. and Guilak, F. and Leong, K. W., Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells, Biomaterials, vol 31 no. 6 (2010), pp. 1299-1306 [abs].
    • Chen, S. and Jones, J. A. and Xu, Y. and Low, H. Y. and Anderson, J. M. and Leong, K. W., Characterization of topographical effects on macrophage behavior in a foreign body response model, Biomaterials, vol 31 no. 13 (2010), pp. 3479-91 [abs].
    • Chen, H. H. and Ho, Y. P. and Jiang, X. and Mao, H. Q. and Wang, T. H. and Leong, K. W., Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET, Nano Today, vol 4 no. 2 (2009), pp. 125-134 [abs].
    • Oney, S. and Lam, R. T. S. and Bompiani, K. M. and Blake, C. M. and Quick, G. and Heidel, J. D. and Liu, J. Y. C. and Mack, B. C. and Davis, M. E. and Leong, K. W. and Sullenger, B. A., Development of universal antidotes to control aptamer activity, Nature Medicine, vol 15 no. 10 (2009), pp. 1224-1228 [abs].