Kam Leong

Image of Kam Leong

Professor of Biomedical Engineering

Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine

Biomaterials Design:

  • design of self-assembled fibers for tissue engineering
  • microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery
  • synthesis of novel quantum dots for biomedical applications

Controlled Drug and Gene Delivery:

  • oral gene delivery for hemophilia A and B
  • non-viral gene delivery to the GI tract
  • oral delivery of antigen genes for vaccination

Tissue Engineering:

  • study of response of stem cells to nanotopographical cues
  • expansion of hematopoietic stem cells
  • nerve guidance channels with drug and gene delivery functions
  • microencapsulation of stem cells and genetically-engineered cells
  • development of bioartificial nucleus pulposus device
  • study of interaction of stem cells with synthetic nanostructured biomaterials

Appointments and Affiliations
    Contact Information:
    Education:

      Curriculum Vitae
      Research Interests:

      Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine.

      Specialties:

      Biological Materials
      Drug Delivery
      Tissue Repair, Tissue Engineering
      Biophotonics
      Nanoscience

      Awards, Honors, and Distinctions:

      • National Academy of Engineering
      • Stansell Family Distinguished Research Award, 2010
      • 3M Pharmaceuticals Recognition Award, Controlled Release Society, 1996
      • Award for Recognition of Pioneering Contribution in Polymer chemistry and Bioomedical Engineering, Chinese-American Chemical Society, 1995
      • Capsugel Award on Innovative Aspects of Controlled Release Research, Controlled Release Society, 1996, 1997, 1998, 2000, 2001
      • Cygnus Recognition Award, Controlled Release Society, 1997
      • Excellence in Guidance of Graduate Student Research, Controlled Release Society
      • Jorge Heller Manuscript Award, Journal of Controlled Release, 2007
      • Proctor & Gamble Recognition Award, Controlled Release Society, 1993
      • Young Investigator Research Achievement Award, Controlled Release Society, July, 1994

      Courses Taught:

        Representative Publications: (More Publications)
          • Ho, Y. P. and Leong, K. W., Quantum dot-based theranostics, Nanoscale, vol 2 no. 1 (2010), pp. 60-68 [abs].
          • Yim, E. K. F. and Darling, E. M. and Kulangara, K. and Guilak, F. and Leong, K. W., Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells, Biomaterials, vol 31 no. 6 (2010), pp. 1299-1306 [abs].
          • Chen, S. and Jones, J. A. and Xu, Y. and Low, H. Y. and Anderson, J. M. and Leong, K. W., Characterization of topographical effects on macrophage behavior in a foreign body response model, Biomaterials, vol 31 no. 13 (2010), pp. 3479-91 [abs].
          • Chen, H. H. and Ho, Y. P. and Jiang, X. and Mao, H. Q. and Wang, T. H. and Leong, K. W., Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET, Nano Today, vol 4 no. 2 (2009), pp. 125-134 [abs].
          • Oney, S. and Lam, R. T. S. and Bompiani, K. M. and Blake, C. M. and Quick, G. and Heidel, J. D. and Liu, J. Y. C. and Mack, B. C. and Davis, M. E. and Leong, K. W. and Sullenger, B. A., Development of universal antidotes to control aptamer activity, Nature Medicine, vol 15 no. 10 (2009), pp. 1224-1228 [abs].