Theo Pilkington Professor of Biomedical Engineering in the Edmund T. Pratt, Jr. School of Engineering
Ashutosh Chilkoti is the Theo Pilkington Professor and the Chair of the Department of Biomedical Engineering at Duke University.
My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technology's that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.
Appointments and Affiliations
- Theo Pilkington Professor of Biomedical Engineering in the Edmund T. Pratt, Jr. School of Engineering
- Professor of Biomedical Engineering
- Professor in the Department of Chemistry
- Member of the Duke Cancer Institute
- Chair of the Department of Biomedical Engineering
- Ph.D. University of Washington, 1991
Chilkoti's research focuses on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, patterned biomaterials, and targeted drug delivery.
Polymer and Protein Engineering
Sensing and Sensor Systems
Cancer diagnostics and therapy
- BME 394: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 570L: Introduction to Biomolecular Engineering (GE, BB, MC)
- BME 791: Graduate Independent Study
- BME 899: Special Readings in Biomedical Engineering
- EGR 391: Projects in Engineering
Representative Publications: (More Publications)
- Bellucci, J. J. and Amiram, M. and Bhattacharyya, J. and McCafferty, D. and Chilkoti, A., Three-in-One Chromatography-Free Purification, Tag Removal, and Site-Specific Modification of Recombinant Fusion Proteins Using Sortase A and Elastin-like Polypeptides, Angewandte Chemie International Edition (2013).
- McDaniel, J. R. and Bhattacharyya, J. and Vargo, K. B. and Hassouneh, W. and Hammer, D. A. and Chilkoti, A., Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation, Angewandte Chemie International Edition, vol 52 no. 6 (2013), pp. 1683--1687.
- Amiram, M. and Luginbuhl, K. M. and Li, X. and Feinglos, M. N. and Chilkoti, A., Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control, Proceedings of the National Academy of Sciences, vol 110 no. 8 (2013), pp. 2792--2797.
- Hubbell, J. A. and Chilkoti, A., Nanomaterials for Drug Delivery, Science, vol 337 no. 6092 (2012), pp. 303--305.
- Amiram, M. and Quiroz, F. G. and Callahan, D. J. and Chilkoti, A., A highly parallel method for synthesizing DNA repeats enables the discovery of "smart" protein polymers, Nature Materials, vol 10 no. 2 (2011), pp. 141--148.
- Gao, W. and Liu, W. and Christensen, T. and Zalutsky, M. R. and Chilkoti, A., In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation, Proceedings of the National Academy of Sciences, vol 107 no. 38 (2010), pp. 16432--16437.
- A. Hucknall and S. Rangarajan and A. Chilkoti, In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins, Advanced Materials, vol 21 no. 23 (2009), pp. 2441 -- 2446 [abs].
- MacKay, J. A. and Chen, M. and McDaniel, J. R. and Liu, W. and Simnick, A. J. and Chilkoti, A., Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection, Nature Materials, vol 8 no. 12 (2009), pp. 993--999.