Ashutosh Chilkoti

Image of Ashutosh Chilkoti

Theo Pilkington Professor of Biomedical Engineering in the Edmund T. Pratt, Jr. School of Engineering

Ashutosh Chilkoti is a professor with Duke's Department of Biomedical Engineering, and Director of the Center for Biologically Inspired Materials and Materials Systems (CBIMMS).

My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technology's that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.

Appointments and Affiliations
  • Theo Pilkington Professor of Biomedical Engineering in the Edmund T. Pratt, Jr. School of Engineering
  • Professor of Biomedical Engineering
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Chemistry
  • Member of the Duke Cancer Institute
  • Chair of the Department of Biomedical Engineering
Contact Information:
Education:

  • Ph.D. University of Washington, 1991

Research Interests:

Chilkoti's research focuses on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, patterned biomaterials, and targeted drug delivery.

Specialties:

Polymer and Protein Engineering
Drug Delivery
Biological Materials
Sensing and Sensor Systems
Diagnostics
Biophotonics
Plasmonics
Cancer diagnostics and therapy

Awards, Honors, and Distinctions:

  • Pritzker Distinguished Lecture Award, Biomedical Engineering Society, 2013
  • Clemson Award for Contributions to the Literature, Society for Biomaterials, 2011
  • Humboldt Senior Researcher Award, Alexander Von Humboldt Foundation, 2010
  • Stansell Family Distinguished Research Award, Duke University, Pratt School of Engineering, 2008
  • Distinguished Research Award, Duke University, Pratt School of Engineering, 2005

Courses Taught:
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 570L: Introduction to Biomolecular Engineering (GE, BB, MC)
  • BME 701S: BME Graduate Seminars
  • BME 702S: BME Graduate Seminars
  • BME 899: Special Readings in Biomedical Engineering
  • EGR 491: Projects in Engineering

Representative Publications: (More Publications)
    • Bellucci, J. J. and Amiram, M. and Bhattacharyya, J. and McCafferty, D. and Chilkoti, A., Three-in-One Chromatography-Free Purification, Tag Removal, and Site-Specific Modification of Recombinant Fusion Proteins Using Sortase A and Elastin-like Polypeptides, Angewandte Chemie International Edition (2013).
    • McDaniel, J. R. and Bhattacharyya, J. and Vargo, K. B. and Hassouneh, W. and Hammer, D. A. and Chilkoti, A., Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation, Angewandte Chemie International Edition, vol 52 no. 6 (2013), pp. 1683--1687.
    • Amiram, M. and Luginbuhl, K. M. and Li, X. and Feinglos, M. N. and Chilkoti, A., Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control, Proceedings of the National Academy of Sciences, vol 110 no. 8 (2013), pp. 2792--2797.
    • Hubbell, J. A. and Chilkoti, A., Nanomaterials for Drug Delivery, Science, vol 337 no. 6092 (2012), pp. 303--305.
    • Amiram, M. and Quiroz, F. G. and Callahan, D. J. and Chilkoti, A., A highly parallel method for synthesizing DNA repeats enables the discovery of "smart" protein polymers, Nature Materials, vol 10 no. 2 (2011), pp. 141--148.
    • Gao, W. and Liu, W. and Christensen, T. and Zalutsky, M. R. and Chilkoti, A., In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation, Proceedings of the National Academy of Sciences, vol 107 no. 38 (2010), pp. 16432--16437.
    • A. Hucknall and S. Rangarajan and A. Chilkoti, In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins, Advanced Materials, vol 21 no. 23 (2009), pp. 2441 -- 2446 [abs].
    • MacKay, J. A. and Chen, M. and McDaniel, J. R. and Liu, W. and Simnick, A. J. and Chilkoti, A., Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection, Nature Materials, vol 8 no. 12 (2009), pp. 993--999.