Kam Leong

Publications

  • Williford, J-M; Wu, J; Ren, Y; Archang, MM; Leong, KW; Mao, H-Q,
    Recent Advances in Nanoparticle-Mediated siRNA Delivery
    , Annual Review of Biomedical Engineering, vol 16 no. 1 (2014), pp. 347-370 [10.1146/annurev-bioeng-071813-105119] [abs].
  • Kulangara, K; Adler, AF; Wang, H; Chellappan, M; Hammett, E; Yasuda, R; Leong, KW, The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons., Biomaterials, vol 35 no. 20 (2014), pp. 5327-5336 [10.1016/j.biomaterials.2014.03.034] [abs].
  • Phua, KK; Nair, SK; Leong, KW, Messenger RNA (mRNA) nanoparticle tumour vaccination., Nanoscale, vol 6 no. 14 (2014), pp. 7715-7729 [10.1039/c4nr01346h] [abs].
  • Phua, KK; Boczkowski, D; Dannull, J; Pruitt, S; Leong, KW; Nair, SK, Whole blood cells loaded with messenger RNA as an anti-tumor vaccine., Advanced healthcare materials, vol 3 no. 6 (2014), pp. 837-842 [10.1002/adhm.201300512] [abs].
  • Xing, Q; Vogt, C; Leong, KW; Zhao, F,
    Highly Aligned Nanofibrous Scaffold Derived from Decellularized Human Fibroblasts
    , Advanced Functional Materials, vol 24 no. 20 (2014), pp. 3027-3035 [10.1002/adfm.201303460] [abs].
  • Chiu, YL; Chan, HF; Phua, KK; Zhang, Y; Juul, S; Knudsen, BR; Ho, YP; Leong, KW, Synthesis of fluorosurfactants for emulsion-based biological applications., ACS Nano, vol 8 no. 4 (2014), pp. 3913-3920 [10.1021/nn500810n] [abs].
  • Cao, C; Chan, HF; Zang, J; Leong, KW; Zhao, X, Harnessing localized ridges for high-aspect-ratio hierarchical patterns with dynamic tunability and multifunctionality., Advanced Materials, vol 26 no. 11 (2014), pp. 1763-1770 [10.1002/adma.201304589] [abs].
  • Hong, S; Jung, Y; Yen, R; Chan, HF; Leong, KW; Truskey, GA; Zhao, X, Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems., Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering, vol 14 no. 3 (2014), pp. 514-521 [10.1039/c3lc51076j] [abs].
  • Lu, M; Ho, Y-P; Grigsby, CL; Nawaz, AA; Leong, KW; Huang, TJ,
    Three-Dimensional Hydrodynamic Focusing Method for Polyplex Synthesis
    , ACS Nano, vol 8 no. 1 (2014), pp. 332-339 [10.1021/nn404193e] [abs].
  • Kulangara, K; Adler, AF; Wang, H; Chellappan, M; Hammett, E; Yasuda, R; Leong, KW, The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons, Biomaterials, vol 35 no. 20 (2014), pp. 5327-5336 [abs].
  • Phua, KK; Staats, HF; Leong, KW; Nair, SK, Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity., Scientific Reports, vol 4 (2014) [10.1038/srep05128] [abs].
  • Xing, Q; Vogt, C; Leong, KW; Zhao, F, Highly aligned nanofibrous scaffold derived from decellularized human fibroblasts, Advanced Functional Materials, vol 24 no. 20 (2014), pp. 3027-3035 [abs].
  • Perez-Pinera, P; Kocak, DD; Vockley, CM; Adler, AF; Kabadi, AM; Polstein, LR; Thakore, PI; Glass, KA; Ousterout, DG; Leong, KW; Guilak, F; Crawford, GE; Reddy, TE; Gersbach, CA, RNA-guided gene activation by CRISPR-Cas9-based transcription factors., Nature Methods, vol 10 no. 10 (2013), pp. 973-976 [10.1038/nmeth.2600] [abs].
  • Zhang, Y; Ho, YP; Chiu, YL; Chan, HF; Chlebina, B; Schuhmann, T; You, L; Leong, KW, A programmable microenvironment for cellular studies via microfluidics-generated double emulsions., Biomaterials, vol 34 no. 19 (2013), pp. 4564-4572 [10.1016/j.biomaterials.2013.03.002] [abs].
  • Phua, KK; Leong, KW; Nair, SK, Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format., Journal of Controlled Release, vol 166 no. 3 (2013), pp. 227-233 [10.1016/j.jconrel.2012.12.029] [abs].
  • Peters, EB; Christoforou, N; Leong, KW; Truskey, GA, Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro., Tissue Engineering Part A: Tissue Engineering, vol 19 no. 5-6 (2013), pp. 697-706 [10.1089/ten.tea.2011.0704] [abs].
  • Zhang, Y; Chan, HF; Leong, KW, Advanced materials and processing for drug delivery: the past and the future., Advanced Drug Delivery Reviews, vol 65 no. 1 (2013), pp. 104-120 [10.1016/j.addr.2012.10.003] [abs].
  • Choy, ATH; Leong, KW; Chan, BP, Chemical modification of collagen improves glycosaminoglycan retention of their co-precipitates, Acta Biomaterialia, vol 9 no. 1 (2013), pp. 4661-4672 [10.1016/j.actbio.2012.09.016] [abs].
  • Son, YJ; Kim, H; Leong, KW; Yoo, HS, Multifunctional nanorods serving as nanobridges to modulate t cell-mediated immunity, ACS Nano, vol 7 no. 11 (2013), pp. 9771-9779 [abs].
  • Godsey, ME; Suryaprakash, S; Leong, KW, Materials innovation for co-delivery of diverse therapeutic cargos, RSC Advances, vol 3 no. 47 (2013), pp. 24794-24811 [abs].
  • Juul, S; Iacovelli, F; Falconi, M; Kragh, SL; Christensen, B; Frøhlich, R; Franch, O; Kristoffersen, EL; Stougaard, M; Leong, KW; Ho, Y-P; Sørensen, ES; Birkedal, V; Desideri, A; Knudsen, BR, Temperature-controlled encapsulation and release of an active enzyme in the cavity of a self-assembled DNA nanocage, ACS Nano, vol 7 no. 11 (2013), pp. 9724-9734 [abs].
  • Chan, HF; Zhang, Y; Ho, YP; Chiu, YL; Jung, Y; Leong, KW, Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment., Scientific Reports, vol 3 (2013) [10.1038/srep03462] [abs].
  • Grigsby, CL; Ho, Y-P; Lin, C; Engbersen, JFJ; Leong, KW, Microfluidic preparation of polymer-nucleic acid nanocomplexes improves nonviral gene transfer, Scientific Reports, vol 3 (2013) [abs].
  • Truskey, GA; Achneck, HE; Bursac, N; Chan, HF; Cheng, CS; Fernandez, C; Hong, S; Jung, Y; Koves, T; Kraus, WE; Leong, K; Madden, L; Reichert, WM; Zhao, X, Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing, Stem Cell Research and Therapy, vol 4 no. SUPPL.1 (2013) [abs].
  • Juul, S; Harmsen, C; Nielsen, MJ; Stougaard, M; Leong, KW; Knudsen, BR; Ho, YP, Single cell enzyme diagnosis on the chip, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (2013), pp. 911-914 [10.1109/MEMSYS.2013.6474392] [abs].
  • Leong, KW; Sung, HW, Nanoparticle- and biomaterials-mediated oral delivery for drug, gene, and immunotherapy, Advanced Drug Delivery Reviews (2013) [10.1016/j.addr.2013.02.002] [abs].
  • Gamboa, JM; Leong, KW, In vitro and in vivo models for the study of oral delivery of nanoparticles, Advanced Drug Delivery Reviews (2013) [10.1016/j.addr.2013.01.003] [abs].
  • Zhang, Y; Chan, HF; Leong, KW, Advanced materials and processing for drug delivery: The past and the future, Advanced Drug Delivery Reviews, vol 65 no. 1 (2013), pp. 104-120 [10.1016/j.addr.2012.10.003] [abs].
  • Zhang, Y; Ho, YP; Chiu, YL; Chan, HF; Chlebina, B; Schuhmann, T; You, L; Leong, KW, A programmable microenvironment for cellular studies via microfluidics-generated double emulsions, Biomaterials, vol 34 no. 19 (2013), pp. 4564-4572 [10.1016/j.biomaterials.2013.03.002] [abs].
  • Chakraborty, S; Christoforou, N; Fattahi, A; Herzog, RW; Leong, KW, A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells., PLoS One, vol 8 no. 5 (2013) [10.1371/journal.pone.0064342] [abs].
  • Christoforou, N; Chellappan, M; Adler, AF; Kirkton, RD; Wu, T; Addis, RC; Bursac, N; Leong, KW, Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming., PLoS One, vol 8 no. 5 (2013) [10.1371/journal.pone.0063577] [abs].
  • Christoforou, N; Liau, B; Chakraborty, S; Chellapan, M; Bursac, N; Leong, KW, Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues., PLoS One, vol 8 no. 6 (2013) [10.1371/journal.pone.0065963] [abs].
  • Leong, KW; Sung, HW, Nanoparticle- and biomaterials-mediated oral delivery for drug, gene, and immunotherapy, Advanced Drug Delivery Reviews, vol 65 no. 6 (2013), pp. 757-758 [10.1016/j.addr.2013.02.002] [abs].
  • Gamboa, JM; Leong, KW, In vitro and in vivo models for the study of oral delivery of nanoparticles, Advanced Drug Delivery Reviews, vol 65 no. 6 (2013), pp. 800-810 [10.1016/j.addr.2013.01.003] [abs].
  • Wang, X; Sherman, A; Liao, G; Leong, KW; Daniell, H; Terhorst, C; Herzog, RW, Mechanism of oral tolerance induction to therapeutic proteins, Advanced Drug Delivery Reviews, vol 65 no. 6 (2013), pp. 759-773 [10.1016/j.addr.2012.10.013] [abs].
  • Chen, J; Lee, EJ; Jing, L; Christoforou, N; Leong, KW; Setton, LA, Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro., PLoS One, vol 8 no. 9 (2013) [10.1371/journal.pone.0075548] [abs].
  • Perez-Pinera, P; Kocak, DD; Vockley, CM; Adler, AF; Kabadi, AM; Polstein, LR; Thakore, PI; Glass, KA; Ousterout, DG; Leong, KW; Guilak, F; Crawford, GE; Reddy, TE; Gersbach, CA, RNA-guided gene activation by CRISPR-Cas9-based transcription factors, Nature Methods, vol 10 no. 10 (2013), pp. 973-976 [10.1038/nmeth.2600] [abs].
  • Diekman, BO; Christoforou, N; Willard, VP; Sun, H; Sanchez-Adams, J; Leong, KW; Guilak, F, Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells., Proceedings of the National Academy of Sciences of USA, vol 109 no. 47 (2012), pp. 19172-19177 [10.1073/pnas.1210422109] [abs].
  • Yang, Y; Kulangara, K; Lam, RT; Dharmawan, R; Leong, KW, Effects of topographical and mechanical property alterations induced by oxygen plasma modification on stem cell behavior., ACS Nano, vol 6 no. 10 (2012), pp. 8591-8598 [10.1021/nn301713d] [abs].
  • Jain, S; Pitoc, GA; Holl, EK; Zhang, Y; Borst, L; Leong, KW; Lee, J; Sullenger, BA, Nucleic acid scavengers inhibit thrombosis without increasing bleeding., Proceedings of the National Academy of Sciences of USA, vol 109 no. 32 (2012), pp. 12938-12943 [10.1073/pnas.1204928109] [abs].
  • Kulangara, K; Yang, Y; Yang, J; Leong, KW, Nanotopography as modulator of human mesenchymal stem cell function., Biomaterials, vol 33 no. 20 (2012), pp. 4998-5003 [10.1016/j.biomaterials.2012.03.053] [abs].
  • Loo, Y; Grigsby, CL; Yamanaka, YJ; Chellappan, MK; Jiang, X; Mao, HQ; Leong, KW, Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models., Journal of Controlled Release, vol 160 no. 1 (2012), pp. 48-56 [10.1016/j.jconrel.2012.01.041] [abs].
  • St John, AL; Chan, CY; Staats, HF; Leong, KW; Abraham, SN, Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes., Nature Materials, vol 11 no. 3 (2012), pp. 250-257 [10.1038/nmat3222] [abs].
  • Pisetsky, DS; Lee, J; Leong, KW; Sullenger, BA, Nucleic acid-binding polymers as anti-inflammatory agents: reducing the danger of nuclear attack., Expert Review of Clinical Immunology, vol 8 no. 1 (2012), pp. 1-3 [10.1586/eci.11.82] [abs].
  • Stearns, NA; Lee, J; Leong, KW; Sullenger, BA; Pisetsky, DS, The inhibition of anti-DNA binding to DNA by nucleic acid binding polymers., PLoS One, vol 7 no. 7 (2012) [10.1371/journal.pone.0040862] [abs].
  • Juul, S; Nielsen, CJF; Labouriau, R; Roy, A; Tesauro, C; Jensen, PW; Harmsen, C; Kristoffersen, EL; Chiu, YL; Frohlich, R; Fiorani, P; Cox-Singh, J; Tordrup, D; Koch, J; Bienvenu, AL; Desideri, A; Picot, S; Petersen, E; Leong, KW; Ho, YP; Stougaard, M; Knudsen, BR, Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement, ACS Nano, vol 6 no. 12 (2012), pp. 10676-10683 [10.1021/nn3038594] [abs].
  • Kolind, K; Leong, KW; Besenbacher, F; Foss, M, Guidance of stem cell fate on 2D patterned surfaces, Biomaterials, vol 33 no. 28 (2012), pp. 6626-6633 [10.1016/j.biomaterials.2012.05.070] [abs].
  • Yang, S; Guo, F; Kiraly, B; Mao, X; Lu, M; Leong, KW; Huang, TJ, Microfluidic synthesis of multifunctional Janus particles for biomedical applications, Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering, vol 12 no. 12 (2012), pp. 2097-2102 [10.1039/c2lc90046g] [abs].
  • Ma, G; Petersen, E; Leong, KW; Liao, K, Mechanical behavior of human embryonic stem cell pellet under unconfined compression, Biomechanics and Modeling in Mechanobiology, vol 11 no. 5 (2012), pp. 703-714 [10.1007/s10237-011-0344-9] [abs].
  • Park, S; Son, YJ; Leong, KW; Yoo, HS, Therapeutic nanorods with metallic multi-segments: Thermally inducible encapsulation of doxorubicin for anti-cancer therapy, Nano Today: an international rapid reviews journal, vol 7 no. 2 (2012), pp. 76-84 [10.1016/j.nantod.2012.02.005] [abs].
  • Grigsby, CL; Ho, YP; Leong, KW, Understanding nonviral nucleic acid delivery with quantum dot-FRET nanosensors, Nanomedicine, vol 7 no. 4 (2012), pp. 565-577 [10.2217/nnm.12.28] [abs].
  • Wang, X; Sherman, A; Liao, G; Leong, KW; Daniell, H; Terhorst, C; Herzog, RW, Mechanism of oral tolerance induction to therapeutic proteins, Advanced Drug Delivery Reviews (2012) [10.1016/j.addr.2012.10.013] [abs].
  • Adler, AF; Grigsby, CL; Kulangara, K; Wang, H; Yasuda, R; Leong, KW, Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells., Molecular Therapy - Nucleic Acids, vol 1 (2012) [10.1038/mtna.2012.25] [abs].
  • Liau, B; Christoforou, N; Leong, KW; Bursac, N, Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function., Biomaterials, vol 32 no. 35 (2011), pp. 9180-9187 [10.1016/j.biomaterials.2011.08.050] [abs].
  • Ye, X; Fels, D; Tovmasyan, A; Aird, KM; Dedeugd, C; Allensworth, JL; Kos, I; Park, W; Spasojevic, I; Devi, GR; Dewhirst, MW; Leong, KW; Batinic-Haberle, I, Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate., Free Radical Research, vol 45 no. 11-12 (2011), pp. 1289-1306 [10.3109/10715762.2011.616199] [abs].
  • Batinic-Haberle, I; Rajic, Z; Tovmasyan, A; Reboucas, JS; Ye, X; Leong, KW; Dewhirst, MW; Vujaskovic, Z; Benov, L; Spasojevic, I, Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics., Free Radical Biology and Medicine, vol 51 no. 5 (2011), pp. 1035-1053 [10.1016/j.freeradbiomed.2011.04.046] [abs].
  • Lee, J; Sohn, JW; Zhang, Y; Leong, KW; Pisetsky, D; Sullenger, BA, Nucleic acid-binding polymers as anti-inflammatory agents., Proceedings of the National Academy of Sciences of USA, vol 108 no. 34 (2011), pp. 14055-14060 [10.1073/pnas.1105777108] [abs].
  • Le, DM; Kulangara, K; Adler, AF; Leong, KW; Ashby, VS, Dynamic topographical control of mesenchymal stem cells by culture on responsive poly(ε-caprolactone) surfaces., Advanced Materials, vol 23 no. 29 (2011), pp. 3278-3283 [10.1002/adma.201100821] [abs].
  • Chalut, KJ; Kulangara, K; Wax, A; Leong, KW, Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture., Integrative Biology, vol 3 no. 8 (2011), pp. 863-867 [10.1039/c1ib00003a] [abs].
  • Yang, Y; Kulangara, K; Sia, J; Wang, L; Leong, KW, Engineering of a microfluidic cell culture platform embedded with nanoscale features., Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering, vol 11 no. 9 (2011), pp. 1638-1646 [10.1039/c0lc00736f] [abs].
  • Adler, AF; Speidel, AT; Christoforou, N; Kolind, K; Foss, M; Leong, KW, High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts., Biomaterials, vol 32 no. 14 (2011), pp. 3611-3619 [10.1016/j.biomaterials.2011.01.040] [abs].
  • Spasojevic, I; Kos, I; Benov, LT; Rajic, Z; Fels, D; Dedeugd, C; Ye, X; Vujaskovic, Z; Reboucas, JS; Leong, KW; Dewhirst, MW; Batinic-Haberle, I, Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site., Free Radical Research, vol 45 no. 2 (2011), pp. 188-200 [10.3109/10715762.2010.522575] [abs].
  • Juul, S; Ho, YP; Stougaard, M; Koch, J; Andersen, FF; Leong, KW; Knudsen, BR, Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, vol 2011 (2011), pp. 3258-3261 [10.1109/IEMBS.2011.6090885] [abs].
  • Li, H; LaBean, TH; Leong, KW, Nucleic acid-based nanoengineering: Novel structures for biomedical applications, Interface Focus, vol 1 no. 5 (2011), pp. 702-724 [10.1098/rsfs.2011.0040] [abs].
  • Juul, S; Ho, YP; Koch, J; Andersen, FF; Stougaard, M; Leong, KW; Knudsen, BR, Detection of single enzymatic events in rare or single cells using microfluidics, ACS Nano, vol 5 no. 10 (2011), pp. 8305-8310 [10.1021/nn203012q] [abs].
  • Wu, Y; Ho, YP; Mao, Y; Wang, X; Yu, B; Leong, KW; Lee, LJ, Uptake and intracellular fate of multifunctional nanoparticles: A comparison between lipoplexes and polyplexes via quantum dot mediated Förster resonance energy transfer, Molecular Pharmaceutics, vol 8 no. 5 (2011), pp. 1662-1668 [10.1021/mp100466m] [abs].
  • Yuan, M; Leong, KW; Chan, BP, Three-dimensional culture of rabbit nucleus pulposus cells in collagen microspheres, The Spine Journal, vol 11 no. 10 (2011), pp. 947-960 [10.1016/j.spinee.2011.07.004] [abs].
  • Dai, H; Jiang, X; Leong, KW; Mao, HQ, Transient depletion of kupffer cells leads to enhanced transgene expression in rat liver following retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles, Human Gene Therapy, vol 22 no. 7 (2011), pp. 873-878 [10.1089/hum.2010.146] [abs].
  • Ho, YP; Grigsby, CL; Zhao, F; Leong, KW, Tuning physical properties of nanocomplexes through microfluidics-assisted confinement, Nano Letters: a journal dedicated to nanoscience and nanotechnology, vol 11 no. 5 (2011), pp. 2178-2182 [10.1021/nl200862n] [abs].
  • Liao, IC; Leong, KW, Efficacy of engineered FVIII-producing skeletal muscle enhanced by growth factor-releasing co-axial electrospun fibers, Biomaterials, vol 32 no. 6 (2011), pp. 1669-1677 [10.1016/j.biomaterials.2010.10.049] [abs].
  • Sun, TM; Du, JZ; Yao, YD; Mao, CQ; Dou, S; Huang, SY; Zhang, PZ; Leong, KW; Song, EW; Wang, J, Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression, ACS Nano, vol 5 no. 2 (2011), pp. 1483-1494 [10.1021/nn103349h] [abs].
  • Juul, S; Ho, YP; Stougaard, M; Koch, J; Andersen, FF; Leong, KW; Knudsen, BR, Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (2011), pp. 3258-3261 [10.1109/IEMBS.2011.6090885] [abs].
  • Ho, YP; Grigsby, C; Leong, KW, Unexpected properties of polymeric DNA-nanocomplexes synthesized in picoliter droplets, NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (2011), pp. 41-44 [10.1109/NEMS.2011.6017290] [abs].
  • Yang, Y; Leong, KW, Nanoscale surfacing for regenerative medicine., Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, vol 2 no. 5 (2010), pp. 478-495 [10.1002/wnan.74] [abs].
  • Staats, HF; Leong, KW, Polymer hydrogels: Chaperoning vaccines., Nature Materials, vol 9 no. 7 (2010), pp. 537-538 [10.1038/nmat2788] [abs].
  • Zhao, F; Veldhuis, JJ; Duan, Y; Yang, Y; Christoforou, N; Ma, T; Leong, KW, Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer., Molecular Therapy, vol 18 no. 5 (2010), pp. 1010-1018 [10.1038/mt.2010.21] [abs].
  • Chen, S; Jones, JA; Xu, Y; Low, HY; Anderson, JM; Leong, KW, Characterization of topographical effects on macrophage behavior in a foreign body response model., Biomaterials, vol 31 no. 13 (2010), pp. 3479-3491 [10.1016/j.biomaterials.2010.01.074] [abs].
  • Chalut, KJ; Kulangara, K; Giacomelli, MG; Wax, A; Leong, KW, Deformation of stem cell nuclei by nanotopographical cues., Soft Matter, vol 6 no. 8 (2010), pp. 1675-1681 [10.1039/B921206J] [abs].
  • Yim, EK; Darling, EM; Kulangara, K; Guilak, F; Leong, KW, Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells., Biomaterials, vol 31 no. 6 (2010), pp. 1299-1306 [10.1016/j.biomaterials.2009.10.037] [abs].
  • Kadiyala, I; Loo, Y; Roy, K; Rice, J; Leong, KW, Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes, European Journal of Pharmaceutical Sciences, vol 39 no. 1-3 (2010), pp. 103-109 [10.1016/j.ejps.2009.11.002] [abs].
  • Jiang, X; Zheng, Y; Chen, HH; Leong, KW; Wang, TH; Mao, HQ, Dual-sensitive micellar nanoparticles regulate dna unpacking and enhance gene-delivery efficiency, Advanced Materials, vol 22 no. 23 (2010), pp. 2556-2560 [10.1002/adma.200903933] [abs].
  • Ho, YP; Leong, KW, Quantum dot-based theranostics., Nanoscale, vol 2 no. 1 (2010), pp. 60-68 [10.1039/b9nr00178f] [abs].
  • Phua, K; Leong, KW, Microscale oral delivery devices incorporating nanoparticles, Nanomedicine, vol 5 no. 2 (2010), pp. 161-163 [10.2217/nnm.09.113] [abs].
  • Grigsby, CL; Leong, KW, Balancing protection and release of DNA: Tools to address a bottleneck of non-viral gene delivery, Journal of the Royal Society Interface, vol 7 no. SUPPL. 1 (2010), pp. S67-S82 [10.1098/rsif.2009.0260] [abs].
  • Christoforou, N; Oskouei, BN; Esteso, P; Hill, CM; Zimmet, JM; Bian, W; Bursac, N; Leong, KW; Hare, JM; Gearhart, JD, Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts., PLoS One, vol 5 no. 7 (2010) [10.1371/journal.pone.0011536] [abs].
  • Adler, AF; Leong, KW, Emerging links between surface nanotechnology and endocytosis: Impact on nonviral gene delivery, Nano Today: an international rapid reviews journal, vol 5 no. 6 (2010), pp. 553-569 [10.1016/j.nantod.2010.10.007] [abs].
  • Wu, Y; Liao, IC; Kennedy, SJ; Du, J; Wang, J; Leong, KW; Clark, RL, Electrosprayed core-shell microspheres for protein delivery, Chemical Communications, vol 46 no. 26 (2010), pp. 4743-4745 [10.1039/c0cc00535e] [abs].
  • Wang, Y; Quek, CH; Leong, KW; Fang, J, Synthesis and cytotoxicity of luminescent InP quantum dots, Materials Research Society Symposium - Proceedings, vol 1241 (2010), pp. 7-12 [abs].
  • Ho, M; Yang, Y; Kulangara, K; Li, H; Zhao, F; Bean, TL; Leong, KW, Microfluidic platforms related to nanomedicine, 7th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2010 (2010), pp. 21-22 [abs].
  • Kunder, CA; St John, AL; Li, G; Leong, KW; Berwin, B; Staats, HF; Abraham, SN, Mast cell-derived particles deliver peripheral signals to remote lymph nodes., Journal of Experimental Medicine, vol 206 no. 11 (2009), pp. 2455-2467 [10.1084/jem.20090805] [abs].
  • Oney, S; Lam, RT; Bompiani, KM; Blake, CM; Quick, G; Heidel, JD; Liu, JY; Mack, BC; Davis, ME; Leong, KW; Sullenger, BA, Development of universal antidotes to control aptamer activity., Nature Medicine, vol 15 no. 10 (2009), pp. 1224-1228 [10.1038/nm.1990] [abs].
  • Yow, SZ; Quek, CH; Yim, EKF; Leong, KW; Lim, CT, A Biofunctional Fibrous Scaffold for the Encapsulation of Human Mesenchymal Stem Cells and its Effects on Stem Cell Differentiation, Ifmbe Proceedings, vol 23 (2009), pp. 1279-1281 [abs].
  • Yow, SZ; Quek, CH; Yim, EKF; Lim, CT; Leong, KW, Collagen-based fibrous scaffold for spatial organization of encapsulated and seeded human mesenchymal stem cells, Biomaterials, vol 30 no. 6 (2009), pp. 1133-1142 [10.1016/j.biomaterials.2008.11.003] [abs].
  • Ho, YP; Chen, HH; Leong, KW; Wang, TH, Combining QD-FRET and microfluidics to monitor DNA nanocomplex self-assembly in real-time, Journal of Visualized Experiments no. 30 (2009) [10.3791/1432] [abs].
  • Kulangara, K; Leong, KW, Substrate topography shapes cell function, Soft Matter, vol 5 no. 21 (2009), pp. 4072-4076 [10.1039/b910132m] [abs].
  • Chakraborty, S; Liao, IC; Adler, A; Leong, KW, Electrohydrodynamics: A facile technique to fabricate drug delivery systems, Advanced Drug Delivery Reviews, vol 61 no. 12 (2009), pp. 1043-1054 [10.1016/j.addr.2009.07.013] [abs].
  • Chen, HH; Ho, YP; Jiang, X; Mao, HQ; Wang, TH; Leong, KW, Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET, Nano Today: an international rapid reviews journal, vol 4 no. 2 (2009), pp. 125-134 [10.1016/j.nantod.2009.02.008] [abs].
  • Ho, YP; Chen, HH; Leong, KW; Wang, TH, The convergence of quantum-dot-mediated fluorescence resonance energy transfer and microfluidics for monitoring DNA polyplex self-assembly in real time, Nanotechnology, vol 20 no. 9 (2009) [10.1088/0957-4484/20/9/095103] [abs].
  • Liao, IC; Chen, S; Liu, JB; Leong, KW, Sustained viral gene delivery through core-shell fibers, Journal of Controlled Release, vol 139 no. 1 (2009), pp. 48-55 [10.1016/j.jconrel.2009.06.007] [abs].
  • Lou, YL; Peng, YS; Chen, BH; Wang, LF; Leong, KW, Poly(ethylene imine)-g-chitosan using EX-810 as a spacer for nonviral gene delivery vectors, Journal of Biomedical Materials Research Part A, vol 88A no. 4 (2009), pp. 1058-1068 [abs].
  • Chen, HH; Ho, YP; Jiang, X; Mao, HQ; Wang, TH; Leong, KW, Erratum to "Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET" [Nano Today 4 (2009) 125-134] (DOI:10.1016/j.nantod.2009.02.008), Nano Today: an international rapid reviews journal, vol 4 no. 3 (2009) [10.1016/j.nantod.2009.04.003] [abs].
  • Lou, YL; Peng, YS; Chen, BH; Wang, LF; Leong, KW, Poly(ethylene imine)-g-chitosan using EX-810 as a spacer for nonviral gene delivery vectors, Journal of Biomedical Materials Research Part A, vol 88 no. 4 (2009), pp. 1058-1068 [10.1002/jbm.a.31961] [abs].
  • Ho, YP; Chen, HH; Leong, KW; Wang, TH, Combining QD-FRET and microfluidics to monitor DNA nanocomplex self-assembly in real-time., Journal of Visualized Experiments no. 30 (2009) [10.3791/1432] [abs].
  • Liao, IC; Liu, JB; Bursac, N; Leong, KW, Effect of Electromechanical Stimulation on the Maturation of Myotubes on Aligned Electrospun Fibers., Cellular and Molecular Bioengineering, vol 1 no. 2-3 (2008), pp. 133-145 [10.1007/s12195-008-0021-y] [abs].
  • Chalut, KJ; Chen, S; Finan, JD; Giacomelli, MG; Guilak, F; Leong, KW; Wax, A, Label-free, high-throughput measurements of dynamic changes in cell nuclei using angle-resolved low coherence interferometry., Biophysical Journal, vol 94 no. 12 (2008), pp. 4948-4956 [10.1529/biophysj.107.124107] [abs].
  • Chew, SY; Mi, R; Hoke, A; Leong, KW, The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation, Biomaterials, vol 29 no. 6 (2008), pp. 653-661 [10.1016/j.biomaterials.2007.10.025] [abs].
  • Chen, HH; Ho, YP; Jiang, X; Mao, HQ; Wang, TH; Leong, KW, Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum Dot-FRET, Molecular Therapy, vol 16 no. 2 (2008), pp. 324-332 [10.1038/sj.mt.6300392] [abs].
  • Chan, BP; Leong, KW, Scaffolding in tissue engineering: General approaches and tissue-specific considerations, European Spine Journal, vol 17 no. SUPPL. 4 (2008), pp. S467-S479 [10.1007/s00586-008-0745-3] [abs].
  • Tsurushima, H; Yuan, X; Dillehay, LE; Leong, KW, Radiation-Inducible Caspase-8 Gene Therapy for Malignant Brain Tumors, International Journal of Radiation: Oncology - Biology - Physics, vol 71 no. 2 (2008), pp. 517-525 [10.1016/j.ijrobp.2008.02.002] [abs].
  • Bowman, K; Sarkar, R; Raut, S; Leong, KW, Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles, Journal of Controlled Release, vol 132 no. 3 (2008), pp. 252-259 [10.1016/j.jconrel.2008.06.019] [abs].
  • Choi, JS; Leong, KW; Yoo, HS, In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF), Biomaterials, vol 29 no. 5 (2008), pp. 587-596 [10.1016/j.biomaterials.2007.10.012] [abs].
  • Prow, TW; Bhutto, I; Kim, SY; Grebe, R; Merges, C; McLeod, DS; Uno, K; Mennon, M; Rodriguez, L; Leong, K; Lutty, GA, Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium, Nanomedicine: Nanotechnology, Biology and Medicine, vol 4 no. 4 (2008), pp. 340-349 [10.1016/j.nano.2008.06.003] [abs].
  • Haider, M; Cappello, J; Ghandehari, H; Leong, KW, In vitro chondrogenesis of mesenchymal stem cells in recombinant silk-elastinlike hydrogels, Pharmaceutical Research, vol 25 no. 3 (2008), pp. 692-699 [10.1007/s11095-007-9282-8] [abs].
  • Yamanaka, YJ; Leong, KW, Engineering strategies to enhance nanoparticle-mediated oral delivery, Journal of Biomaterials Science: Polymer Edition, vol 19 no. 12 (2008), pp. 1549-1570 [10.1163/156856208786440479] [abs].
  • Tan, SCW; Pan, WX; Ma, G; Cai, N; Leong, KW; Liao, K, Viscoelastic behaviour of human mesenchymal stem cells, BMC Cell Biology, vol 9 (2008) [10.1186/1471-2121-9-40] [abs].
  • Ho, YP; Chen, HH; Puleo, CM; Yeh, HC; Leong, KW; Wang, TH, Quantitative kinetic analysis of DNA nanocomplex self-assembly with quantum dots fret in a microfluidic device, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (2008), pp. 30-33 [10.1109/MEMSYS.2008.4443585] [abs].
  • Nori, A; Yim, EKF; Chen, S; Leong, KW, Cell-Substrate Interactions, Principles of Regenerative Medicine (2008), pp. 666-685 [10.1016/B978-012369410-2.50040-1] [abs].
  • Bursac, N; Loo, Y; Leong, K; Tung, L, Novel anisotropic engineered cardiac tissues: studies of electrical propagation., Biochemical and Biophysical Research Communications, vol 361 no. 4 (2007), pp. 847-853 [10.1016/j.bbrc.2007.07.138] [abs].
  • Chen, B; Dang, J; Tan, TL; Fang, N; Chen, WN; Leong, KW; Chan, V, Dynamics of smooth muscle cell deadhesion from thermosensitive hydroxybutyl chitosan, Biomaterials, vol 28 no. 8 (2007), pp. 1503-1514 [10.1016/j.biomaterials.2006.11.027] [abs].
  • Park, DJ; Choi, JH; Leong, KW; Kwon, JW; Eun, HS, Tissue-engineered bone formation with gene transfer and mesenchymal stem cells in a minimally invasive technique, The Laryngoscope, vol 117 no. 7 (2007), pp. 1267-1271 [10.1097/MLG.0b013e31805f680e] [abs].
  • Tsurushima, H; Yuan, X; Dillehay, LE; Leong, KW, Radioresponsive tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy for malignant brain tumors, Cancer Gene Therapy, vol 14 no. 8 (2007), pp. 706-716 [10.1038/sj.cgt.7701065] [abs].
  • Chai, C; Leong, KW, Biomaterials approach to expand and direct differentiation of stem cells, Molecular Therapy, vol 15 no. 3 (2007), pp. 467-480 [10.1038/sj.mt.6300084] [abs].
  • Zhang, Y; Chai, C; Jiang, XS; Teoh, SH; Leong, KW, Fibronectin immobilized by covalent conjugation or physical adsorption shows different bioactivity on aminated-PET, Materials Science and Engineering C: Biomimetic and Supramolecular Systems, vol 27 no. 2 (2007), pp. 213-219 [10.1016/j.msec.2006.03.013] [abs].
  • Song, R; Liu, S; Leong, KW, Effects of MIP-1α, MIP-3α, and MIP-3β on the induction of HIV gag-specific immune response with DNA vaccines, Molecular Therapy, vol 15 no. 5 (2007), pp. 1007-1015 [10.1038/mt.sj.6300129] [abs].
  • Yim, EKF; Liao, IC; Leong, KW, Tissue compatibility of interfacial polyelectrolyte complexation fibrous scaffold: Evaluation of blood compatibility and biocompatibility, Tissue Engineering, vol 13 no. 2 (2007), pp. 423-433 [10.1089/ten.2006.0113] [abs].
  • Sharma, B; Williams, CG; Kim, TK; Sun, D; Malik, A; Khan, M; Leong, K; Elisseeff, JH, Designing zonal organization into tissue-engineered cartilage, Tissue Engineering, vol 13 no. 2 (2007), pp. 405-414 [10.1089/ten.2006.0068] [abs].
  • Chua, KN; Tang, YN; Quek, CH; Ramakrishna, S; Leong, KW; Mao, HQ, A dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes, Acta Biomaterialia, vol 3 no. 5 (2007), pp. 643-650 [10.1016/j.actbio.2007.03.012] [abs].
  • Chua, KN; Chai, C; Lee, PC; Ramakrishna, S; Leong, KW; Mao, HQ, Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells, Experimental Hematology, vol 35 no. 5 (2007), pp. 771-781 [10.1016/j.exphem.2007.02.002] [abs].
  • Yim, EKF; Pang, SW; Leong, KW, Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage, Experimental Cell Research, vol 313 no. 9 (2007), pp. 1820-1829 [10.1016/j.yexcr.2007.02.031] [abs].
  • Chew, SY; Mi, R; Hoke, A; Leong, KW, Aligned protein-polymer composite fibers enhance nerve regeneration: A potential tissue-engineering platform, Advanced Functional Materials, vol 17 no. 8 (2007), pp. 1288-1296 [10.1002/adfm.200600441] [abs].
  • Tsurushima, H; Yuan, X; Dillehay, LE; Leong, KW, Radio-responsive gene therapy for malignant glioma cells without the radiosensitive promoter: Caspase-3 gene therapy combined with radiation, Cancer Letters, vol 246 no. 1-2 (2007), pp. 318-323 [10.1016/j.canlet.2006.03.015] [abs].
  • Dang, JM; Leong, KW, Myogenic induction of aligned mesenchymal stem cell sheets by culture on thermally responsive electrospun nanofibers, Advanced Materials, vol 19 no. 19 (2007), pp. 2775-2779 [10.1002/adma.200602159] [abs].
  • Dai, H; Jiang, X; Tan, GCY; Chen, Y; Torbenson, M; Leong, KW; Mao, HQ, Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery, International Journal of Nanomedicine, vol 1 no. 4 (2006), pp. 507-522 [10.2147/nano.2006.1.4.507] [abs].
  • Visage, CL; Kim, SW; Tateno, K; Sieber, AN; Kostuik, JP; Leong, KW, Interaction of human mesenchymal stem cells with disc cells: Changes in extracellular matrix biosynthesis, Spine, vol 31 no. 18 (2006), pp. 2036-2042 [10.1097/01.brs.0000231442.05245.87] [abs].
  • Ong, SY; Dai, H; Leong, KW, Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture, Biomaterials, vol 27 no. 22 (2006), pp. 4087-4097 [10.1016/j.biomaterials.2006.03.022] [abs].
  • Bright, C; Park, YS; Sieber, AN; Kostuik, JP; Leong, KW, In vivo evaluation of plasmid DNA encoding OP-1 protein for spine fusion, Spine, vol 31 no. 19 (2006), pp. 2163-2172 [10.1097/01.brs.0000232721.59901.45] [abs].
  • Yim, EKF; Wan, ACA; Visage, CL; Liao, IC; Leong, KW, Proliferation and differentiation of human mesenchymal stem cell encapsulated in polyelectrolyte complexation fibrous scaffold, Biomaterials, vol 27 no. 36 (2006), pp. 6111-6122 [10.1016/j.biomaterials.2006.07.037] [abs].
  • Luong-Van, E; Grøndahl, L; Chua, KN; Leong, KW; Nurcombe, V; Cool, SM, Controlled release of heparin from poly(ε-caprolactone) electrospun fibers, Biomaterials, vol 27 no. 9 (2006), pp. 2042-2050 [10.1016/j.biomaterials.2005.10.028] [abs].
  • Dang, JM; Leong, KW, Natural polymers for gene delivery and tissue engineering, Advanced Drug Delivery Reviews, vol 58 no. 4 (2006), pp. 487-499 [10.1016/j.addr.2006.03.001] [abs].
  • Li, J; Li, X; Ni, X; Wang, X; Li, H; Leong, KW, Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and α-cyclodextrin for controlled drug delivery, Biomaterials, vol 27 no. 22 (2006), pp. 4132-4140 [10.1016/j.biomaterials.2006.03.025] [abs].
  • Yim, EKF; Wen, J; Leong, KW, Enhanced extracellular matrix production and differentiation of human embryonic germ cell derivatives in biodegradable poly(ε-caprolactone-co-ethyl ethylene phosphate) scaffold, Acta Biomaterialia, vol 2 no. 4 (2006), pp. 365-376 [10.1016/j.actbio.2006.03.006] [abs].
  • Chew, SY; Hufnagel, TC; Lim, CT; Leong, KW, Mechanical properties of single electrospun drug-encapsulated nanofibres, Nanotechnology, vol 17 no. 15 (2006), pp. 3880-3891 [10.1088/0957-4484/17/15/045] [abs].
  • Zhang, Y; Chai, C; Jiang, XS; Teoh, SH; Leong, KW, Co-culture of umbilical cord blood CD34+ cells with human mesenchymal stem cells, Tissue Engineering, vol 12 no. 8 (2006), pp. 2161-2170 [10.1089/ten.2006.12.2161] [abs].
  • Chen, HH; Leong, KW, Quantum-dots-FRET nanosensors for detecting unamplified nucleic acids by single molecule detection, Nanomedicine, vol 1 no. 1 (2006), pp. 119-122 [abs].
  • Wu, D; Liu, Y; Jiang, X; He, C; Goh, SH; Leong, KW, Hyperbranched poly(amino ester)s with different terminal amine groups for DNA delivery, Biomacromolecules, vol 7 no. 6 (2006), pp. 1879-1883 [10.1021/bm0601878] [abs].
  • Li, Q; Wang, J; Shahani, S; Sun, DDN; Sharma, B; Elisseeff, JH; Leong, KW, Biodegradable and photocrosslinkable polyphosphoester hydrogel, Biomaterials, vol 27 no. 7 (2006), pp. 1027-1034 [10.1016/j.biomaterials.2005.07.019] [abs].
  • Bowman, K; Leong, KW, Chitosan nanoparticles for oral drug and gene delivery, International Journal of Nanomedicine, vol 1 no. 2 (2006), pp. 117-128 [10.2147/nano.2006.1.2.117] [abs].
  • Jiang, XS; Chai, C; Zhang, Y; Zhuo, RX; Mao, HQ; Leong, KW, Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbilical cord blood CD34+ cells, Biomaterials, vol 27 no. 13 (2006), pp. 2723-2732 [10.1016/j.biomaterials.2005.12.001] [abs].
  • Tsurushima, H; Yoshii, Y; Leong, KW; Ohno, T, Targeted tumor cell death induced by autologous tumor-specific T lymphocyte recognition of wild-type p53-derived peptides, Journal of Neuro-Oncology, vol 76 no. 2 (2006), pp. 99-104 [10.1007/s11060-005-4172-6] [abs].
  • Lim, SH; Liao, IC; Leong, KW, Nonviral Gene Delivery from Nonwoven Fibrous Scaffolds Fabricated by Interfacial Complexation of Polyelectrolytes, Molecular Therapy, vol 13 no. 6 (2006), pp. 1163-1172 [10.1016/j.ymthe.2005.12.016] [abs].
  • Song, R; Liu, S; Adams, RJ; Leong, KW, Enhancing efficacy of HIV Gag DNA vaccine by local delivery of GM-CSF in murine and macaque models, Journal of Interferon and Cytokine Research, vol 26 no. 6 (2006), pp. 380-389 [10.1089/jir.2006.26.380] [abs].
  • Dang, JM; Sun, DDN; Shin-Ya, Y; Sieber, AN; Kostuik, JP; Leong, KW, Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells, Biomaterials, vol 27 no. 3 (2006), pp. 406-418 [10.1016/j.biomaterials.2005.07.033] [abs].
  • Jiang, X; Dai, H; Leong, KW; Goh, SH; Mao, HQ; Yang, YY, Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions, Journal of Gene Medicine, vol 8 no. 4 (2006), pp. 477-487 [10.1002/jgm.868] [abs].
  • Li, J; Yang, C; Li, H; Wang, X; Goh, SH; Ding, JL; Wang, DY; Leong, KW, Cationic supramolecules composed of multiple oligoethylenimine-grafted β-cyclodextrins threaded on a polymer chain for efficient gene delivery, Advanced Materials, vol 18 no. 22 (2006), pp. 2969-2974 [10.1002/adma.200600812] [abs].
  • Visage, CL; Yang, SH; Kadakia, L; Sieber, AN; Kostuik, JP; Leong, KW, Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration, Spine, vol 31 no. 21 (2006), pp. 2423-2430 [10.1097/01.brs.0000238684.04792.eb] [abs].
  • Chew, SY; Wen, Y; Dzenis, Y; Leong, KW, The role of electrospinning in the emerging field of nanomedicine, Current Pharmaceutical Design, vol 12 no. 36 (2006), pp. 4751-4770 [10.2174/138161206779026326] [abs].
  • Chua, KN; Chai, C; Lee, PC; Tang, YN; Ramakrishna, S; Leong, KW; Mao, HQ, Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood hematopoietic stem/progenitor cells, Biomaterials, vol 27 no. 36 (2006), pp. 6043-6051 [10.1016/j.biomaterials.2006.06.017] [abs].
  • Feng, Q; Chai, C; Jiang, XS; Leong, KW; Mao, HQ, Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin, Journal of Biomedical Materials Research Part A, vol 78A no. 4 (2006), pp. 781-791 [abs].
  • Wong, K; Sun, G; Zhang, X; Dai, H; Liu, Y; He, C; Leong, KW, PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo, Bioconjugate Chemistry, vol 17 no. 1 (2006), pp. 152-158 [10.1021/bc0501597] [abs].
  • Ho, YP; Chen, HH; Leong, KW; Wang, TH, Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET, Journal of Controlled Release, vol 116 no. 1 (2006), pp. 83-89 [10.1016/j.jconrel.2006.09.005] [abs].
  • Li, X; Mya, KY; Ni, X; He, C; Leong, KW; Li, J, Dynamic and static light scattering studies on self-aggregation behavior of biodegradable amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]- poly(ethylene oxide) triblock copolymers in aqueous solution, The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical, vol 110 no. 12 (2006), pp. 5920-5926 [10.1021/jp057004g] [abs].
  • Liao, IC; Chew, SY; Leong, KW, Aligned core-shell nanofibers delivering bioactive proteins, Nanomedicine, vol 1 no. 4 (2006), pp. 465-471 [10.2217/17435889.1.4.465] [abs].
  • Ong, SY; Dai, H; Leong, KW, Hepatic differentiation potential of commercially available human mesenchymal stem cells, Tissue Engineering, vol 12 no. 12 (2006), pp. 3477-3485 [10.1089/ten.2006.12.3477] [abs].
  • Feng, Q; Chai, C; Jiang, XS; Leong, KW; Mao, HQ, Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin, Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol 78 no. 4 (2006), pp. 781-791 [10.1002/jbm.a.30829] [abs].
  • Hollinger, JO; Leong, K, Poly(α-hydroxy acids). Carriers for bone morphogenetic proteins, The Biomaterials: Silver Jubilee Compendium (2006), pp. 139-146 [10.1016/B978-008045154-1.50018-6] [abs].
  • Leong, KW, Polymeric controlled nucleic acid delivery, Materials Research Society (MRS) Bulletin, vol 30 no. 9 (2005), pp. 640-646 [abs].
  • Yim, EKF; Leong, KW, Significance of synthetic nanostructures in dictating cellular response, Nanomedicine: Nanotechnology, Biology and Medicine, vol 1 no. 1 (2005), pp. 10-21 [10.1016/j.nano.2004.11.008] [abs].
  • Lu, HF; Lim, WS; Zhang, PC; Chia, SM; Yu, H; Mao, HQ; Leong, KW, Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture, Tissue Engineering, vol 11 no. 11-12 (2005), pp. 1667-1677 [10.1089/ten.2005.11.1667] [abs].
  • Zhang, XQ; Wang, XL; Huang, SW; Zhuo, RX; Liu, ZL; Mao, HQ; Leong, KW, In vitro gene delivery using polyamidoamine dendrimers with a trimesyl core, Biomacromolecules, vol 6 no. 1 (2005), pp. 341-350 [10.1021/bm040060n] [abs].
  • Chua, KN; Lim, WS; Zhang, P; Lu, H; Wen, J; Ramakrishna, S; Leong, KW; Mao, HQ, Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold, Biomaterials, vol 26 no. 15 (2005), pp. 2537-2547 [10.1016/j.biomaterials.2004.07.040] [abs].
  • Chia, SM; Lin, PC; Quek, CH; Yin, C; Mao, HQ; Leong, KW; Xu, X; Goh, CH; Ng, ML; Yu, H, Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells, Journal of Biotechnology, vol 118 no. 4 (2005), pp. 434-447 [10.1016/j.jbiotec.2005.05.012] [abs].
  • Li, J; Ni, X; Li, X; Tan, NK; Lim, CT; Ramakrishna, S; Leong, KW, Micellization phenomena of biodegradable amphiphilic triblock copolymers consisting of poly(β-hydroxyalkanoic acid) and poly(ethylene oxide), Langmuir: the ACS journal of surfaces and colloids, vol 21 no. 19 (2005), pp. 8681-8685 [10.1021/la0515266] [abs].
  • Tan, WJ; Teo, GP; Liao, K; Leong, KW; Mao, HQ; Chan, V, Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface, Biomaterials, vol 26 no. 8 (2005), pp. 891-898 [10.1016/j.biomaterials.2004.03.041] [abs].
  • Myoung, SK; Hwang, NS; Lee, J; Kim, TK; Leong, K; Shamblott, MJ; Gearhart, J; Elisseeff, J, Musculoskeletal differentiation of cells derived from human embryonic germ cells, Stem Cells, vol 23 no. 1 (2005), pp. 113-123 [10.1634/stemcells.2004-0110] [abs].
  • Liu, Y; Wu, DC; Zhang, WD; Jiang, X; He, CB; Chung, TS; Goh, SH; Leong, KW, Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA, Angewandte Chemie - International Edition, vol 44 no. 30 (2005), pp. 4782-4785 [10.1002/anie.200500042] [abs].
  • Zhang, PC; Wang, J; Leong, KW; Mao, HQ, Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency, Biomacromolecules, vol 6 no. 1 (2005), pp. 54-60 [10.1021/bm040010i] [abs].
  • Pan, W; Petersen, E; Cai, N; Ma, G; Lee, JR; Feng, Z; Liao, K; Leong, KW, Viscoelastic properties of human mesenchymal stem cells, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol 7 VOLS (2005), pp. 4854-4857 [abs].
  • Mao, HQ; Shipanova-Kadiyala, I; Zhao, Z; Dang, W; Brown, A; Leong, KW, Biodegradable poly(terephthalate-co-phosphate)s: Synthesis, characterization and drug-release properties, Journal of Biomaterials Science: Polymer Edition, vol 16 no. 2 (2005), pp. 135-161 [10.1163/1568562053115426] [abs].
  • Chen, HH; Visage, CL; Qiu, B; Du, X; Ouwerkerk, R; Leong, KW; Yang, X, MR imaging of biodegradable polymeric microparticles: A potential method of monitoring local drug delivery, Magnetic Resonance in Medicine, vol 53 no. 3 (2005), pp. 614-620 [10.1002/mrm.20395] [abs].
  • Wu, D; Liu, Y; Jiang, X; Chen, L; He, C; Goh, SH; Leong, KW, Evaluation of hyperbranched poly(amino ester)s of amine constitutions similar to polyethlenimine for DNA delivery, Biomacromolecules, vol 6 no. 6 (2005), pp. 3166-3173 [10.1021/bm0504983] [abs].
  • Salem, AK; Hung, CF; Kim, TW; Wu, TC; Searson, PC; Leong, KW, Multi-component nanorods for vaccination applications, Nanotechnology, vol 16 no. 4 (2005), pp. 484-487 [10.1088/0957-4484/16/4/025] [abs].
  • Yim, EKF; Reano, RM; Pang, SW; Yee, AF; Chen, CS; Leong, KW, Nanopattern-induced changes in morphology and motility of smooth muscle cells, Biomaterials, vol 26 no. 26 (2005), pp. 5405-5413 [10.1016/j.biomaterials.2005.01.058] [abs].
  • Lu, HF; Chua, KN; Zhang, PC; Lim, WS; Ramakrishna, S; Leong, KW; Mao, HQ, Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance, Acta Biomaterialia, vol 1 no. 4 (2005), pp. 399-410 [10.1016/j.actbio.2005.04.003] [abs].
  • Chew, SY; Wen, J; Yim, EKF; Leong, KW, Sustained release of proteins from electrospun biodegradable fibers, Biomacromolecules, vol 6 no. 4 (2005), pp. 2017-2024 [10.1021/bm0501149] [abs].
  • Fang, N; Wee, JT; Leong, KW; Mao, HQ; Chan, V, pH responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylene terephthalate) surface, Colloids and Surfaces B: Biointerfaces, vol 42 no. 3-4 (2005), pp. 245-252 [10.1016/j.colsurfb.2004.11.002] [abs].
  • Yim, EKF; Leong, KW, Proliferation and differentiation of human embryonic germ cell derivatives in bioactive polymeric fibrous scaffold, Journal of Biomaterials Science: Polymer Edition, vol 16 no. 10 (2005), pp. 1193-1217 [10.1163/156856205774269485] [abs].
  • Kuang, M; Liu, SQ; Saijo, K; Uchimura, E; Huang, L; Leong, KW; Lu, MD; Huang, JF; Ohno, T, Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity, International Journal of Hyperthermia, vol 21 no. 3 (2005), pp. 247-257 [10.1080/02656730500052027] [abs].
  • Zhang, XQ; Wang, XL; Zhang, PC; Liu, ZL; Zhuo, RX; Mao, HQ; Leong, KW, Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes, Journal of Controlled Release, vol 102 no. 3 (2005), pp. 749-763 [10.1016/j.jconrel.2004.10.024] [abs].
  • Mao, HQ; Leong, KW, Design of Polyphosphoester-DNA Nanoparticles for Non-Viral Gene Delivery, Advances in Genetics, vol 53 (2005), pp. 275-306 [10.1016/S0065-2660(05)53011-6] [abs].
  • Liao, IC; Wan, ACA; Yim, EKF; Leong, KW, Controlled release from fibers of polyelectrolyte complexes, Journal of Controlled Release, vol 104 no. 2 (2005), pp. 347-358 [10.1016/j.jconrel.2005.02.013] [abs].
  • Hu, W; Yim, EKF; Reano, RM; Leong, KW; Pang, SW, Effects of nanoimprinted patterns in tissue-culture polystyrene on cell behavior, Journal of Vacuum Science and Technology Part B: Microelectronics and Nanometer Structures, vol 23 no. 6 (2005), pp. 2984-2989 [10.1116/1.2121729] [abs].
  • Guan, J; Fei, Z; Loo, Y; Leong, KW; Lee, LJ, Dynamic self-assembly and characterization of DNA-polycation nanoparticles, AIChE Annual Meeting, Conference Proceedings (2005) [abs].
  • Bini, TB; Gao, S; Xu, X; Wang, S; Ramakrishna, S; Leong, KW, Peripheral nerve regeneration by microbraided poly(L-lactide-co-glycolide) biodegradable polymer fibers, Journal of Biomedical Materials Research - Part A, vol 68 no. 2 (2004), pp. 286-295 [abs].
  • Wan, ACA; Yim, EKF; Liao, IC; Visage, CL; Leong, KW, Encapsulation of biologics in self-assembled fibers as biostructural units for tissue engineering, Journal of Biomedical Materials Research - Part A, vol 71 no. 4 (2004), pp. 586-595 [10.1002/jbm.a.30158] [abs].
  • Wan, ACA; Mao, HQ; Wang, S; Phua, SH; Lee, GP; Pan, J; Lu, S; Wang, J; Leong, KW, Poly(phosphoester) ionomers as tissue-engineering scaffolds, Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol 70 no. 1 (2004), pp. 91-102 [abs].
  • Li, Y; Wang, J; Lee, CGL; Wang, CY; Gao, SJ; Tang, GP; Ma, YX; Yu, H; Mao, HQ; Leong, KW; Wang, S, CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: A comparison with polyethylenimine/DNA complexes, Gene Therapy, vol 11 no. 1 (2004), pp. 109-114 [10.1038/sj.gt.3302135] [abs].
  • Kuang, M; Peng, BG; Lu, MD; Liang, LJ; Huang, JF; He, Q; Hua, YP; Totsuka, S; Liu, SQ; Leong, KW; Ohno, T, Phase II Randomized Trial of Autologous Formalin-Fixed Tumor Vaccine for Postsurgical Recurrence of Hepatocellular Carcinoma, Clinical Cancer Research, vol 10 no. 5 (2004), pp. 1574-1579 [10.1158/1078-0432.CCR-03-0071] [abs].
  • Li, X; Li, J; Leong, KW, Role of intermolecular interaction between hydrophobic blocks in block-selected inclusion complexation of amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) triblock copolymers with cyclodextrins, Polymer, vol 45 no. 20 (2004), pp. 6845-6851 [10.1016/j.polymer.2004.07.038] [abs].
  • Faranesh, AZ; Nastley, MT; Cruz, CPDL; Haller, MF; Laquerriere, P; Leong, KW; McVeigh, ER, In vitro release of vascular endothelial growth factor from gadolinium-doped biodegradable microspheres, Magnetic Resonance in Medicine, vol 51 no. 6 (2004), pp. 1265-1271 [10.1002/mrm.20092] [abs].
  • Sun, DDN; Leong, KW, A nonlinear hyperelastic mixture theory model for anisotropy, transport, and swelling of annulus fibrosus, Annals of Biomedical Engineering, vol 32 no. 1 (2004), pp. 92-102 [10.1023/B:ABME.0000007794.87408.1e] [abs].
  • Wan, ACA; Mao, HQ; Wang, S; Phua, SH; Lee, GP; Pan, JS; Lu, S; Wang, J; Leong, KW, Poly(phosphoester) ionomers as tissue-engineering scaffolds, Journal of Biomedical Materials Research Part B-Applied Biomaterials, vol 70B no. 1 (2004), pp. 91-102 [abs].
  • Salem, AK; Chao, J; Leong, KW; Searson, PC, Receptor-mediated self-assembly of multi-component magnetic nanowires, Advanced Materials, vol 16 no. 3 (2004), pp. 268-271 [abs].
  • Le Visage, C; Dunham, B; Flint, P; Leong, KW, Coculture of mesenchymal stem cells and respiratory epithelial cells to engineer a human composite respiratory mucosa, Tissue Engineering, vol 10 no. 9-10 (2004), pp. 1426-1435 [10.1089/1076327042500247] [abs].
  • Wen, J; Mao, HQ; Li, W; Lin, KY; Leong, KW, Biodegradable polyphosphoester micelles for gene delivery, Journal of Pharmaceutical Sciences, vol 93 no. 8 (2004), pp. 2142-2157 [10.1002/jps.20121] [abs].
  • Chan, V; Liu, KK; Visage, CL; Ju, BF; Leong, KW, Bioadhesive characterization of poly(methylidene malonate 2.12) microparticle on model extracellular matrix, Biomaterials, vol 25 no. 18 (2004), pp. 4327-4332 [10.1016/j.biomaterials.2003.11.021] [abs].
  • Wang, J; Sun, DN; Shin-ya, Y; Leong, KW, Stimuli-responsive hydrogel based on poly(propylene phosphate), Macromolecules, vol 37 no. 2 (2004), pp. 670-672 [10.1021/ma035453d] [abs].
  • Huang, SW; Wang, J; Zhang, PC; Mao, HQ; Zhuo, RX; Leong, KW, Water-soluble and nonionic polyphosphoester: Synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle, Biomacromolecules, vol 5 no. 2 (2004), pp. 306-311 [10.1021/bm034241l] [abs].
  • Quek, CH; Li, J; Sun, T; Chan, MLH; Mao, HQ; Gan, LM; Leong, KW; Yu, H, Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation, Biomaterials, vol 25 no. 17 (2004), pp. 3531-3540 [10.1016/j.biomaterials.2003.09.112] [abs].
  • Wang, J; Gao, SJ; Zhang, PC; Wang, S; Mao, HQ; Leong, KW, Polyphosphoramidate gene carriers: Effect of charge group on gene transfer efficiency, Gene Therapy, vol 11 no. 12 (2004), pp. 1001-1010 [10.1038/sj.gt.3302248] [abs].
  • Bini, TB; Gao, SJ; Xu, XY; Wang, S; Ramakrishna, S; Leong, KW, Peripheral nerve regeneration by microbraided poly(L-lactide-co-glycolide) biodegradable polymer fibers, Journal of Biomedical Materials Research Part A, vol 68A no. 2 (2004), pp. 286-295 [abs].
  • Wang, J; Lee, IL; Lim, WS; Chia, SM; Yu, H; Leong, KW; Mao, HQ, Evaluation of collagen and methylated collagen as gene carriers, International Journal of Pharmaceutics, vol 279 no. 1-2 (2004), pp. 115-126 [10.1016/j.ijpharm.2004.04.014] [abs].
  • Wan, ACA; Liao, IC; Yim, EKF; Leong, KW, Mechanism of fiber formation by interfacial polyelectrolyte complexation, Macromolecules, vol 37 no. 18 (2004), pp. 7019-7025 [10.1021/ma0498868] [abs].
  • Li, Q; Williams, CG; Sun, DDN; Wang, J; Leong, K; Elisseeff, JH, Photocrosslinkable polysaccharides based on chondroitin sulfate, Journal of Biomedical Materials Research Part A, vol 68A no. 1 (2004), pp. 28-33 [abs].
  • Shin-Ya, Y; Tsurushima, H; Tsurumi, T; Kajiuchi, T; Leong, KW, Polyelectrolyte complex films derived from polyethyleneoxide-maleic acid copolymer and chitosan: Preparation and characterization, Macromolecular Bioscience, vol 4 no. 5 (2004), pp. 526-531 [10.1002/mabi.200300110] [abs].
  • Kiang, T; Bright, C; Cheung, CY; Stayton, PS; Hoffman, AS; Leong, KW, Formulation of chitosan-DNA nanoparticles with poly(propyl acrylic acid) enhances gene expression, Journal of Biomaterials Science, Polymer Edition, vol 15 no. 11 (2004), pp. 1405-1421 [10.1163/1568562042368112] [abs].
  • Kiang, T; Wen, J; Lim, HW; Leong, KW, The effect of the degree of chitosan deacetylation on the efficiency of gene transfection, Biomaterials, vol 25 no. 22 (2004), pp. 5293-5301 [10.1016/j.biomaterials.2003.12.036] [abs].
  • Salem, AK; Chen, M; Hayden, J; Leong, KW; Searson, PC, Directed assembly of multisegment Au/Pt/Au nanowires, Nano Letters, vol 4 no. 6 (2004), pp. 1163-1165 [10.1021/nl049462r] [abs].
  • Visage, CL; Rioux-Leclercq, N; Haller, M; Breton, P; Malavaud, B; Leong, K, Efficacy of paclitaxel released from bio-adhesive polymer microspheres on model superficial bladder cancer, Journal of Urology, vol 171 no. 3 (2004), pp. 1324-1329 [10.1097/01.ju.0000103922.12319.59] [abs].
  • Wan, ACA; Yim, EKF; Liao, IC; Le Visage, C; Leong, KW, Encapsulation of biologics in self-assembled fibers as biostructural units for tissue engineering, Journal of Biomedical Materials Research Part A, vol 71A no. 4 (2004), pp. 586-595 [abs].
  • Visage, CL; Dunham, B; Flint, P; Leong, KW, Coculture of mesenchymal stem cells and respiratory epithelial cells to engineer a human composite respiratory mucosa, Tissue Engineering, vol 10 no. 9-10 (2004), pp. 1426-1435 [10.1089/ten.2004.10.1426] [abs].
  • Li, J; Ni, X; Leong, K, Erratum: Block-selected molecular recognition and formation of polypseudorotaxanes between poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) triblock copolymers and α-cyclodextrin (Angewandte Chemie - International Edition (2003) 42 (69-72)), Angewandte Chemie - International Edition, vol 43 no. 25 (2004) [10.1002/anie.200490081] [abs].
  • Yim, EKF; Wan, A; Liao, I; Visage, CL; Leong, KW, Osteogenic and chondrogenic differentiation of human mesenchymal stem cells incorporated into polyelectrolyte fibrous scaffold, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Salem, AK; Searson, PC; Leong, KW, Multifunctional nanorods for gene delivery, Materials Research Society Symposium - Proceedings, vol EXS no. 1 (2004), pp. 455-457 [abs].
  • Chai, C; Feng, Q; Jiang, XS; Leong, KW; Mao, HQ, Expansion of CD34+ cells on polymeric scaffolds surface-immobilized with hematopoietic growth factors, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Chua, KN; Lim, WS; Lu, HF; Chai, C; Zhang, PC; Wen, J; Ramakrishna, S; Leong, KW; Mao, HQ, Immobilized hepatocyte spheroids on galactose ligand-conjugated nanofiber scaffold, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Leong, KW; Liao, IC; Yim, E; Lim, S; Wan, A; Wen, J; Chew, SY; Chua, KN; Ramakrishna, S; Mao, HQ, Controlled release systems designed for regenerative medicine, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Quek, CH; Li, J; Sun, T; Chan, MLH; Mao, HQ; Gan, LM; Leong, KW; Yu, H, Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Li, J; Ni, X; Li, X; Wang, X; Zhou, Z; Leong, KW, A novel biodegradable amphiphilic triblock copolymer consisting of poly[(R)-β-hydroxybutyrate] and poly(ethylene oxide) and Its self-association property, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Li, X; Ni, XP; Zhou, ZH; Leong, KW; Li, J, Injectable supramolecular hydrogels based on poly(ethylene oxide)-b-poly[(R)-3-hydroxybutyrate]-b-poly(ethylene oxide) triblock copolymers and α-cyclodextrin, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Wan, ACA; Yim, EKF; Liao, IC; Chai, C; Leong, KW, The assembly of "biostructural units" as a new strategy for tissue engineering, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Feng, Q; Jiang, XS; Chai, C; Lim, WS; Leong, KW; Mao, HQ, Ex vivo expansion of hematopoietic primitive cells on ECM molecule-immobilized scaffold, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Lim, WS; Chua, KN; Wang, XL; Zhang, PC; Lu, HF; Leong, KW; Mao, HQ, Transfection of rat primary hepatocytes using a novel polyphosphoramidate gene carrier, Transactions - 7th World Biomaterials Congress (2004) [abs].
  • Li, Q; Williams, CG; Sun, DDN; Wang, J; Leong, K; Elisseeff, JH, Photocrosslinkable polysaccharides based on chondroitin sulfate, Journal of Biomedical Materials Research - Part A, vol 68 no. 1 (2004), pp. 28-33 [abs].
  • Li, J; Ni, X; Leong, KW, Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide)s and α-cyclodextrin, Journal of Biomedical Materials Research - Part A, vol 65 no. 2 (2003), pp. 196-202 [abs].
  • Yin, C; Ying, L; Zhang, PC; Zhuo, RX; Kang, ET; Leong, KW; Mao, HQ, High density of immobilized galactose ligand enhances hepatocyte attachment and function, Journal of Biomedical Materials Research - Part A, vol 67 no. 4 (2003), pp. 1093-1104 [abs].
  • Liu, XM; Yang, YY; Leong, KW, Thermally responsive polymeric micellar nanoparticles self-assembled from cholesteryl end-capped random poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide): Synthesis, temperature-sensitivity, and morphologies, Journal of Colloid and Interface Science, vol 266 no. 2 (2003), pp. 295-303 [10.1016/S0021-9797(03)00691-X] [abs].
  • Li, J; Li, X; Ni, X; Leong, KW, Synthesis and characterization of new biodegradable amphiphilic poly(ethylene oxide)-b-poly [(R)-3-hydroxy butyrate]-b-poly(ethylene oxide) triblock copolymers, Macromolecules, vol 36 no. 8 (2003), pp. 2661-2667 [10.1021/ma025725x] [abs].
  • Xu, X; Yee, WC; Hwang, PYK; Yu, H; Wan, ACA; Gao, S; Boon, KL; Mao, HQ; Leong, KW; Wang, S, Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits, Biomaterials, vol 24 no. 13 (2003), pp. 2405-2412 [10.1016/S0142-9612(03)00109-1] [abs].
  • Wen, J; Kim, GJA; Leong, KW, Poly(D,Llactide-co-ethyl ethylene phosphate)s as new drug carriers, Journal of Controlled Release, vol 92 no. 1-2 (2003), pp. 39-48 [10.1016/S0168-3659(03)00294-3] [abs].
  • Yin, C; Chia, SM; Quek, CH; Yu, H; Zhuo, RX; Leong, KW; Mao, HQ, Microcapsules with improved mechanical stability for hepatocyte culture, Biomaterials, vol 24 no. 10 (2003), pp. 1771-1780 [10.1016/S0142-9612(02)00580-X] [abs].
  • Li, J; Ni, XP; Leong, KW, Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide) and alpha-cyclodextrin, Journal of Biomedical Materials Research Part A, vol 65A no. 2 (2003), pp. 196-202 [abs].
  • Salem, AK; Searson, PC; Leong, KW, Multifunctional nanorods for gene delivery, Nature Materials, vol 2 no. 10 (2003), pp. 668-671 [10.1038/nmat974] [abs].
  • Du, X; Yang, Y; Visage, CL; Chen, HH; DeJong, R; Qiu, B; Wang, D; Leong, KW; Hamper, UM; Yang, X, In vivo US monitoring of catheter-based vascular delivery of gene microspheres in pigs: Feasibility, Radiology, vol 228 no. 2 (2003), pp. 555-559 [10.1148/radiol.2282020539] [abs].
  • Chew, JL; Wolfowicz, CB; Mao, HQ; Leong, KW; Chua, KY, Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice, Vaccine, vol 21 no. 21-22 (2003), pp. 2720-2729 [10.1016/S0264-410X(03)00228-7] [abs].
  • Lu, HF; Lim, WS; Wang, J; Tang, ZQ; Zhang, PC; Leong, KW; Chia, SM; Yu, H; Mao, HQ, Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance, Biomaterials, vol 24 no. 27 (2003), pp. 4893-4903 [10.1016/S0142-9612(03)00404-6] [abs].
  • Ying, L; Yin, C; Zhuo, RX; Leong, KW; Mao, HQ; Kang, ET; Neoh, KG, Immobilization of galactose ligands on acrylic acid graft-copolymerized poly(ethylene terephthalate) film and its application to hepatocyte culture, Biomacromolecules, vol 4 no. 1 (2003), pp. 157-165 [10.1021/bm025676w] [abs].
  • Fang, N; Wang, J; Mao, HQ; Leong, KW; Chan, V, BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer, Colloids and Surfaces B: Biointerfaces, vol 29 no. 4 (2003), pp. 233-245 [10.1016/S0927-7765(02)00207-2] [abs].
  • Zhao, Z; Wang, J; Mao, HQ; Leong, KW, Polyphosphoesters in drug and gene delivery, Advanced Drug Delivery Reviews, vol 55 no. 4 (2003), pp. 483-499 [10.1016/S0169-409X(03)00040-1] [abs].
  • Shi, L; Tang, GP; Gao, SJ; Ma, YX; Liu, BH; Li, Y; Zeng, JM; Ng, YK; Leong, KW; Wang, S, Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord, Gene Therapy, vol 10 no. 14 (2003), pp. 1179-1188 [10.1038/sj.gt.3301970] [abs].
  • Li, X; Li, J; Leong, KW, Preparation and characterization of inclusion complexes of biodegradable amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) triblock copolymers with cyclodextrins, Macromolecules, vol 36 no. 4 (2003), pp. 1209-1214 [10.1021/ma0213347] [abs].
  • Li, J; Ni, X; Leong, K, Block-selected molecular recognition and formation of polypseudorotaxanes between poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) triblock copolymers and α-cyclodextrin, Angewandte Chemie International Edition, vol 42 no. 1 (2003), pp. 69-72 [10.1002/anie.200390055] [abs].
  • Wang, J; Huang, SW; Zhang, PC; Mao, HQ; Leong, KW, Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters, International Journal of Pharmaceutics, vol 265 no. 1-2 (2003), pp. 75-84 [10.1016/j.ijpharm.2003.07.006] [abs].
  • Yin, C; Ying, L; Zhang, PC; Zhuo, RX; Kang, ET; Leong, KW; Mao, HQ, High density of immobilized galactose ligand enhances hepatocyte attachment and function, Journal of Biomedical Materials Research Part A, vol 67A no. 4 (2003), pp. 1093-1104 [abs].
  • Sun, T; Chan, MLH; Zhou, Y; Xu, X; Zhang, J; Lao, X; Wang, X; Quek, CH; Chen, JP; Leong, KW; Yu, H, Use of ultrathin shell microcapsules of hepatocytes in bioartificial liver-assist device, Tissue Engineering, vol 9 no. SUPPL. 1 (2003), pp. S65-S75 [abs].
  • Li, J; Ni, X; Zhou, Z; Leong, KW, Preparation and characterization of polypseudorotaxanes based on block-selected inclusion complexation between poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) triblock copolymers and α-cyclodextrin, Journal of the American Chemical Society, vol 125 no. 7 (2003), pp. 1788-1795 [10.1021/ja026623p] [abs].
  • Yin, C; Liao, K; Mao, HQ; Leong, KW; Zhuo, RX; Chan, V, Adhesion contact dynamics of HepG2 cells on galactose-immobilized substrates, Biomaterials, vol 24 no. 5 (2003), pp. 837-850 [10.1016/S0142-9612(02)00416-7] [abs].
  • Peng, B; Liang, L; Liu, S; Huang, J; He, Q; Lu, M; Leong, KW; Ohno, T, Fixed-tumor vaccine: A practical formulation with cytokine-microspheres for protective and therapeutic antitumor immunity, Chinese-German Journal of Clinical Oncology, vol 2 no. 4 (2003), pp. 196-202 [10.1007/BF02835455] [abs].
  • Du, XY; Yang, YS; Le Visage, C; Chen, HH; DeJong, R; Wang, DM; Leong, KW; Hamper, UM; Yang, XM, In vivo ultrasound imaging of catheter-based vascular gene/microsphere delivery, Circulation, vol 106 no. 19 (2002), pp. M-M [abs].
  • Chan, V; Mao, HQ; Leong, KW, Chitosan-induced perturbation of dipalmitoyl-sn-glycero-3-phosphocholine membrane bilayer, Langmuir: the ACS journal of surfaces and colloids, vol 17 no. 12 (2002), pp. 3749-3756 [10.1021/la001754u] [abs].
  • Chia, SM; Wan, ACA; Quek, CH; Mao, HQ; Xu, X; Shen, L; Ng, ML; Leong, KW; Yu, H, Multi-layered microcapsules for cell encapsulation, Biomaterials, vol 23 no. 3 (2002), pp. 849-856 [10.1016/S0142-9612(01)00191-0] [abs].
  • Wang, J; Zhang, PC; Lu, HF; Ma, N; Wang, S; Mao, HQ; Leong, KW, New polyphosphoramidate with a spermidine side chain as a gene carrier, Journal of Controlled Release, vol 83 no. 1 (2002), pp. 157-168 [10.1016/S0168-3659(02)00180-3] [abs].
  • Chew, JL; Fu, TQH; Mao, HQ; Leong, KW; Chua, KY, Oral administration of major house dust mite allergen genes complexed with chitosan elicits protective Th1-skewed immunity in mice, Allergy, vol 57 (2002), pp. 64-64 [abs].
  • Fang, N; Chan, V; Wan, KT; Mao, HQ; Leong, KW, Colloidal adhesion of phospholipid vesicles: High-resolution reflection interference contrast microscopy and theory, Colloids and Surfaces B: Biointerfaces, vol 25 no. 4 (2002), pp. 347-362 [10.1016/S0927-7765(01)00336-8] [abs].
  • Xu, X; Yu, H; Gao, S; Mao, HQ; Leong, KW; Wang, S, Polyphosphoester microspheres for sustained release of biologically active nerve growth factor, Biomaterials, vol 23 no. 17 (2002), pp. 3765-3772 [10.1016/S0142-9612(02)00116-3] [abs].
  • Wang, J; Zhang, PC; Mao, HQ; Leong, KW, Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier, Gene Therapy, vol 9 no. 18 (2002), pp. 1254-1261 [10.1038/sj.gt.3301794] [abs].
  • Kumar, M; Mohapatra, SS; Behera, AK; Lockey, RF; Zhang, J; Bhullar, G; Cruz, CPDL; Chen, LC; Leong, KW; Huang, SK, Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection, Human Gene Therapy, vol 13 no. 12 (2002), pp. 1415-1425 [10.1089/10430340260185058] [abs].
  • Peng, BG; Liu, SQ; Kuang, M; He, Q; Totsuka, S; Huang, L; Huang, J; Lu, MD; Liang, LJ; Leong, KW; Ohno, T, Autologous fixed tumor vaccine: A formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma, Japanese Journal of Cancer Research, vol 93 no. 4 (2002), pp. 363-368 [abs].
  • Chia, SM; Zhou, Y; Sun, T; Mao, HQ; Leong, KW; Chen, JP; Yu, H, Issues and technologies leading to a new bio-artificial liver with microencapsulated hepatocytes, Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products (2002) [abs].
  • Wan, ACA; Mao, HQ; Wang, S; Leong, KW; Ong, LKLL; Yu, H, Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity, Biomaterials, vol 22 no. 10 (2001), pp. 1147-1156 [10.1016/S0142-9612(00)00355-0] [abs].
  • Hanes, J; Sills, A; Zhao, Z; Suh, KW; Tyler, B; DiMeco, F; Brat, DJ; Choti, MA; Leong, KW; Pardoll, EM; Brem, H, Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors, Pharmaceutical Research, vol 18 no. 7 (2001), pp. 899-906 [10.1023/A:1010963307097] [abs].
  • Wang, S; Ma, N; Gao, SJ; Yu, H; Leong, KW, Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes, Molecular Therapy, vol 3 no. 5 (2001), pp. 658-664 [abs].
  • Li, J; Li, X; Zhou, Z; Ni, X; Leong, KW, Formation of supramolecular hydrogels induced by inclusion complexation between pluronics and α-cyclodextrin [2], Macromolecules, vol 34 no. 21 (2001), pp. 7236-7237 [10.1021/ma010742s] [abs].
  • Ramakrishna, S; Mayer, J; Wintermantel, E; Leong, KW, Biomedical applications of polymer-composite materials: A review, Composites Science and Technology, vol 61 no. 9 (2001), pp. 1189-1224 [10.1016/S0266-3538(00)00241-4] [abs].
  • Mao, HQ; Roy, K; Troung-Le, VL; Janes, KA; Lin, KY; Wang, Y; August, JT; Leong, KW, Chitosan-DNA nanoparticles as gene carriers: Synthesis, characterization and transfection efficiency, Journal of Controlled Release, vol 70 no. 3 (2001), pp. 399-421 [10.1016/S0168-3659(00)00361-8] [abs].
  • Wang, S; Wan, ACA; Xu, X; Gao, S; Mao, HQ; Leong, KW; Yu, H, A new nerve guide conduit material composed of a biodegradable poly(phosphoester), Biomaterials, vol 22 no. 10 (2001), pp. 1157-1169 [10.1016/S0142-9612(00)00356-2] [abs].
  • Wang, J; Mao, HQ; Leong, KW, A novel biodegradable gene carrier based on polyphosphoester [19], Journal of the American Chemical Society, vol 123 no. 38 (2001), pp. 9480-9481 [10.1021/ja016062m] [abs].
  • Fang, N; Chan, V; Mao, HQ; Leong, KW, Interactions of phospholipid bilayer with chitosan: Effect of molecular weight and pH, Biomacromolecules, vol 2 no. 4 (2001), pp. 1161-1168 [10.1021/bm015548s] [abs].
  • Li, J; Li, X; Toh, KC; Ni, X; Zhou, Z; Leong, KW, Inclusion complexation and formation of polypseudorotaxanes between poly[(ethylene oxide)-ran-(propylene oxide)] and cyclodextrins, Macromolecules, vol 34 no. 26 (2001), pp. 8829-8831 [10.1021/ma011129b] [abs].
  • Wang, S; Ma, N; Gao, SJ; Yu, H; Leong, KW, Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes, Molecular Therapy, vol 3 no. 5 I (2001), pp. 658-664 [10.1006/mthe.2001.0324] [abs].
  • III, RWG; Leong, KW; August, JT, Antigen-specific induction of peripheral T cell tolerance in vivo by codelivery of DNA vectors encoding antigen and Fas ligand, Human Gene Therapy, vol 11 no. 6 (2000), pp. 851-858 [10.1089/10430340050015464] [abs].
  • Chia, SM; Leong, KW; Li, J; Xu, X; Zeng, K; Er, PN; Gao, S; Yu, H, Hepatocyte encapsulation for enhanced cellular functions, Tissue Engineering, vol 6 no. 5 (2000), pp. 481-495 [10.1089/107632700750022134] [abs].
  • Visage, CL; Malavaud, B; Haller, M; Leong, K, Intravesical administration of paclitaxel encapsulated in poly(methylidene malonate 2.1.2) microparticles, Annals of Biomedical Engineering, vol 28 no. SUPPL. 1 (2000), pp. S-21 [abs].
  • Cruz, CPDL; Haller, M; Malavaud, B; Leong, K, Polymeric gene delivery to the lung, Annals of Biomedical Engineering, vol 28 no. SUPPL. 1 (2000), pp. S-21 [abs].
  • Haller, M; Malavaud, B; Visage, CL; Leong, K, Bladder instillation of DNA-polyphosphoester nanospheres: transport, transfection, and immune responses, Annals of Biomedical Engineering, vol 28 no. SUPPL. 1 (2000), pp. S-23 [abs].
  • Kalyanasundaram, S; Feinstein, S; Nicholson, JP; Leong, KW; Jr, RIG, Coacervate microspheres as carriers of recombinant adenoviruses, Cancer Gene Therapy, vol 6 no. 2 (1999), pp. 107-112 [abs].
  • Truong-Le, VL; Walsh, SM; Schweibert, E; Mao, HQ; Guggino, WB; August, JT; Leong, KW, Gene transfer by DNA-gelatin nanospheres, Archives of Biochemistry and Biophysics, vol 361 no. 1 (1999), pp. 47-56 [10.1006/abbi.1998.0975] [abs].
  • Roy, K; Mao, HQ; Huang, SK; Leong, KW, Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy, Nature Medicine, vol 5 no. 4 (1999), pp. 387-391 [10.1038/7385] [abs].
  • Haller, MF; Mao, HQ; Leong, KW, Intramuscular co-delivery of DNA and cytokines from biodegradable microspheres alters the immune response, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol 1 (1999) [abs].
  • Chia, SM; Li, J; Xu, X; Gao, S; Leong, KW; Yu, H, Novel hepatocyte encapsulation enhances cellular functions, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol 2 (1999) [abs].
  • Cruz, CDL; Liu, SQ; Leong, KW, Mechanistic investigation of different cytokine controlled release systems in generating systemic anti-tumor immunity, Proceedings of the Controlled Release Society no. 26 (1999), pp. 1066-1067 [abs].
  • Liu, SQ; Leong, KW, Adjuvant effect of GM-CSF-HSA/heparin microparticles in cancer immunotherapy, Proceedings of the Controlled Release Society no. 26 (1999), pp. 136-137 [abs].
  • Roy, K; Chu, W; McGrath, J; Kuo, SC; Huang, SK; Leong, KW, Nanoparticle mediated oral gene delivery for DNA vaccination, Proceedings of the International Symposium on Controlled Release of Bioactive Materials no. 26 (1999), pp. 161-162 [abs].
  • Mao, HQ; Lin, KY; Liu, SQ; Haller, MF; Leong, KW, Intramuscular delivery of plasmid encapsulated in biodegradable poly(D,L-lactide-co-phosphate) microspheres, Proceedings of the Controlled Release Society no. 26 (1999), pp. 30-31 [abs].
  • Leong, KW; Mao, HQ; Truong-Le, VL; Roy, K; Walsh, SM; August, JT, DNA-polycation nanospheres as non-viral gene delivery vehicles, Journal of Controlled Release, vol 53 no. 1-3 (1998), pp. 183-193 [10.1016/S0168-3659(97)00252-6] [abs].
  • Truong-Le, VL; August, JT; Leong, KW, Controlled gene delivery by DNA-gelatin nanospheres, Human Gene Therapy, vol 9 no. 12 (1998), pp. 1709-1717 [abs].
  • Leong, KW; Mao, HQ; Truong Le, VL; Roy, K; Walsh, SM; August, JT, DNA-polycation nanospheres as non-viral gene delivery vehicles, Journal of Controlled Release, vol 53 no. 1-3 (1998), pp. 183-193 [abs].
  • Brown, KE; Leong, K; Huang, CH; Dalal, R; Green, GD; Haimes, HB; Jimenez, PA; Bathon, J, Gelatin/chondroitin 6-sulfate microspheres for the delivery of therapeutic proteins to the joint, Arthritis and Rheumatism, vol 41 no. 12 (1998), pp. 2185-2195 [10.1002/1529-0131(199812)41:12<2185::AID-ART13>3.0.CO;2-C] [abs].
  • Shipanova-Kadiyala, I; Liu, S; Mao, HQ; Leong, KW, Polymeric controlled delivery of IL-2 and doxorubicin against a murine melanoma model, Proceedings of the Controlled Release Society no. 25 (1998), pp. 984-985 [abs].
  • Mao, HQ; Hendriks, BS; Lin, KY; Leong, KW, Intramuscular delivery of LacZ plasmid encapsulated in microspheres composed of biodegradable phosphate chain-extended poly(L-lactide), Proceedings of the Controlled Release Society no. 25 (1998), pp. 203-204 [abs].
  • Liu, SQ; Leong, KW, Evaluation of cytokine-containing HSA/heparin microparticles in generating tumor-specific CTL and systemic anti-tumor immunity, Proceedings of the Controlled Release Society no. 25 (1998), pp. 272-273 [abs].
  • Roy, K; Mao, HQ; Lin, KY; Lin, J; Huang, SK; Leong, KW, Oral immunization with DNA-chitosan nanospheres, Proceedings of the International Symposium on Controlled Release of Bioactive Materials no. 25 (1998), pp. 348-349 [abs].
  • Hanes, J; Suh, K; Tyler, B; DiMeco, F; Brat, D; Choti, M; Leong, K; Pardoll, D; Brem, H, Local interleukin-2 delivery eradicates brain and liver tumors, Proceedings of the Controlled Release Society no. 25 (1998), pp. 253-254 [abs].
  • Hu, WP; Wang, LF; Leong, KW, Synthesis and characterization of methacrylic derivatives as drug carriers, Drug Development and Industrial Pharmacy, vol 23 no. 7 (1997), pp. 671-678 [abs].
  • Kalyanasundaram, S; Leong, KW, Intracranial drug delivery systems, Journal of Drug Delivery Science and Technology, vol 7 no. 1 (1997), pp. 62-70 [abs].
  • Kalyanasundaram, S; Calhoun, VD; Leong, KW, A finite element model for predicting the distribution of drugs delivered intracranially to the brain, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol 42 no. 5 (1997), pp. R1810-R1821 [abs].
  • Kalyanasundaram, S; Feinstein, S; Nicholson, JP; Leong, KW; Garver, RI, Recombinant adenovirus can be encapsulated and released from coacervate microspheres in a time-dependent fashion, Cancer Gene Therapy, vol 4 no. 6 (1997), pp. O40-O40 [abs].
  • Roy, K; Mao, HQ; Leong, KW, DNA-chitosan nanospheres: Transfection efficiency and cellular uptake, Proceedings of the Controlled Release Society no. 24 (1997), pp. 673-674 [abs].
  • Liu, SQ; Leong, KW, Delivery of protein and low-molecular weight drug by coacervate of human serum albumin and heparin, Proceedings of the Controlled Release Society no. 24 (1997), pp. 911-912 [abs].
  • Walsh, SM; Flotte, TR; Troung-Le, VL; Rubenstien, R; Beck, S; August, T; Zeitlin, P; Leong, KW, Combination of drug and gene delivery by gelatin nanospheres for the treatment of cystic fibrosis, Proceedings of the International Symposium on Controlled Release of Bioactive Materials no. 24 (1997), pp. 75-76 [abs].
  • Mao, HQ; Roy, K; Truong-Le, V; Leong, KW, DNA-chitosan nanospheres: Derivatization and storage stability, Proceedings of the International Symposium on Controlled Release of Bioactive Materials no. 24 (1997), pp. 671-672 [abs].
  • Kalyanasundaram, S; Calhoun, VD; Leong, KW, A finite element model for predicting the distribution of drugs delivered intracranially to the brain, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol 273 no. 5 42-5 (1997), pp. R1810-R1821 [abs].
  • Truong-Le, VL; Mao, HQ; Walsh, S; Leong, KW; August, JT, Delivery of DNA vaccine using gelatin-DNA nanospheres, Proceedings of the International Symposium on Controlled Release of Bioactive Materials no. 24 (1997), pp. 39-40 [abs].
  • Gutsche, AT; Zurlo, J; Deyesu, E; Leong, KW, Rat hepatocyte morphology and function on lactose-derivatized polystyrene surfaces, Biotechnology and Bioengineering, vol 49 no. 3 (1996), pp. 259-265 [10.1002/(SICI)1097-0290(19960205)49:3<259::AID-BIT3>3.0.CO;2-J] [abs].
  • Zhao, Z; Leong, KW, Controlled delivery of antigens and adjuvants in vaccine development, Journal of Pharmaceutical Sciences, vol 85 no. 12 (1996), pp. 1261-1270 [10.1021/js9602812] [abs].
  • Hollinger, JO; Leong, K, Poly(α-hydroxy acids): Carriers for bone morphogenetic proteins, Biomaterials, vol 17 no. 2 (1996), pp. 187-194 [10.1016/0142-9612(96)85763-2] [abs].
  • Lo, H; Kadiyala, S; Guggino, SE; Leong, KW, Poly(L-lactic acid) foams with cell seeding and controlled-release capacity, Journal of Biomedical Materials Research, vol 30 no. 4 (1996), pp. 475-484 [10.1002/(SICI)1097-4636(199604)30:43.0.CO;2-M] [abs].
  • Gutsche, AT; Lo, H; Zurlo, J; Yager, J; Leong, KW, Engineering of a sugar-derivatized porous network for hepatocyte culture, Biomaterials, vol 17 no. 3 (1996), pp. 387-393 [10.1016/0142-9612(96)85577-3] [abs].
  • Lesser, GJ; Grossman, SA; Leong, KW; Lo, H; Eller, S, In vitro and in vivo studies of subcutaneous hydromorphone implants designed for the treatment of cancer pain, Pain, vol 65 no. 2-3 (1996), pp. 265-272 [10.1016/0304-3959(95)00248-0] [abs].
  • Lo, H; Kadiyala, S; Guggino, SE; Leong, KW, Poly(L-lactic acid) foams with cell seeding and controlled-release capacity, Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol 30 no. 4 (1996), pp. 475-484 [10.1002/(SICI)1097-4636(199604)30:4<475::AID-JBM5>3.0.CO;2-M] [abs].
  • Kadiyala, S; Lo, H; Ponticiello, MS; Reddi, AH; Leong, KW, Bone induction achieved by controlled release of BMP from PLA/hydroxyapatite foams, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium, vol 1 (1996) [abs].
  • Rabowsky, JH; Dukes, AJ; Lee, DA; Leong, KW, The use of bioerodible polymers and daunorubicin in glaucoma filtration surgery, Ophthalmology, vol 103 no. 5 (1996), pp. 800-807 [abs].
  • Jr, SAS; Zhao, Z; Wessem, KV; Crongeyer, J; Tyler, B; Ewend, MG; Leong, K; Brem, H, Intracranial delivery of interleukin-2 by microspheres in the treatment of brain tumors, Proceedings of the Controlled Release Society no. 23 (1996), pp. 855-856 [abs].
  • Mao, HQ; Roy, K; Walsh, SM; August, JT; Leong, KW, DNA-Chitosan nanospheres for gene delivery, Proceedings of the International Symposium on Controlled Release of Bioactive Materials no. 23 (1996), pp. 401-402 [abs].
  • Kalyanasundaram, S; Zhao, Z; Sills, A; Brem, H; Leong, KW, Controlled release for immunotherapy: Analysis of intracranial transport of IL-2, Proceedings of the Controlled Release Society no. 23 (1996), pp. 119-120 [abs].
  • Zhao, Z; Jaffee, EM; Thomas, MC; Pardoll, DM; Leong, KW, GM-CSF microspheres in cancer immunotherapy - A mechanistic study of the vaccine site, Proceedings of the Controlled Release Society no. 23 (1996), pp. 91-92 [abs].
  • Walsh, SM; Flotte, TR; Beck, S; Allen, S; Guggino, WB; August, T; Leong, KW, Delivery of CFTR gene to rabbit airways by gelatin-DNA microspheres, Proceedings of the Controlled Release Society no. 23 (1996), pp. 73-74 [abs].
  • Leong, KW; Mao, H; Zhuo, R, Biodegradable polymers with a phosphoryl-containing backbone: tissue engineering and controlled drug delivery applications, Chinese Journal of Polymer Science (English Edition), vol 13 no. 4 (1995), pp. 289-314 [abs].
  • Dahiyat, BI; Richards, M; Leong, KW, Controlled release from poly(phosphoester) matrices, Journal of Controlled Release, vol 33 no. 1 (1995), pp. 13-21 [abs].
  • Reisfeld, B; Kalyanasundaram, S; Leong, K, A mathematical model of polymeric controlled drug release and transport in the brain, Journal of Controlled Release, vol 36 no. 3 (1995), pp. 199-207 [abs].
  • Dahiyat, BI; Posadas, EM; Hirosue, S; Hostin, E; Leong, KW, Degradable biomaterials with elastomeric characteristics and drug-carrier function, Reactive and Functional Polymers, vol 25 no. 2-3 (1995), pp. 101-109 [abs].
  • Shao, W; Leong, KW, Microcapsules obtained from complex coacervation of collagen and chondroitin sulfate., Journal of Biomaterials Science: Polymer Edition, vol 7 no. 5 (1995), pp. 389-399 [abs].
  • Leong, KW, Alternative materials for fracture fixation., Connective tissue research, vol 31 no. 4 (1995), pp. S69-S75 [abs].
  • Truong-Le, VL; Walsh, SM; August, JT; Leong, KW, Gene transfer by gelatin-DNA coacervate, Proceedings of the Controlled Release Society no. 22 (1995), pp. 466-467 [abs].
  • Zhao, Z; Jaffee, EM; Thomas, MC; Pardoll, DM; Leong, KW, Controlled delivery of cytokines for therapeutic cancer vaccination, Proceedings of the Controlled Release Society no. 22 (1995), pp. 51-52 [abs].
  • Truong, VL; Williams, JR; Hildreth, JEK; Leong, KW, Targeted delivery of immunomicrospheres in vivo, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents, vol 2 no. 3-4 (1995), pp. 166-174 [abs].
  • Shao, W; Leong, KW, Enzymatically degradable synthetic polymers, Materials Research Society Symposium - Proceedings, vol 394 (1995), pp. 199-204 [abs].
  • Heller, PF; Jenkins, GM; Cheng, L; Leong, K; Shao, W; Brinker, J; Hope, E; Nater, C; Lakatta, E; Froelich, JP, Sustained release of galardin and taxol from gelatin chondroitin sulfate coacervate films, Materials Research Society Symposium - Proceedings, vol 394 (1995), pp. 55-60 [abs].
  • Brown, KE; Bathon, J; Huang, CH; Dalal, R; Leong, KW, Cationic gelatin as a gene carrier, Materials Research Society Symposium - Proceedings, vol 394 (1995), pp. 61-66 [abs].
  • Lin, ST; Krebs, SL; Kadiyala, S; Leong, KW; LaCourse, WC; Kumar, B, Development of bioabsorbable glass fibres, Biomaterials, vol 15 no. 13 (1994), pp. 1057-1061 [10.1016/0142-9612(94)90091-4] [abs].
  • Uppal, P; Jampel, HD; Quigley, HA; Leong, KW, Pharmacokinetics of etoposide delivery by a bioerodible drug carrier implanted at glaucoma surgery, Journal of Ocular Pharmacology, vol 10 no. 2 (1994), pp. 471-479 [abs].
  • Gutsche, AT; Parsons-Wingerter, P; Chand, D; Saltzman, WM; Leong, KW, N-acetylglucosamine and adenosine derivatized surfaces for cell culture: 3T3 fibroblast and chicken hepatocyte response, Biotechnology and Bioengineering, vol 43 no. 8 (1994), pp. 801-809 [abs].
  • Kalyanasundaram, S; Calhoun, VD; Leong, KW, Coupled Convective-Diffusive Mass-Transport in the Brain, Faseb Journal, vol 8 no. 4 (1994), pp. A14-A14 [abs].
  • Gutsche, AT; Zurlo, J; Lo, H; Leong, KW, Synthesis and characterization of polymer substrates for rat hepatocyte culture, Materials Research Society Symposium - Proceedings, vol 330 (1994), pp. 243-248 [abs].
  • Truong, VL; Guarnieri, FG; Hildreth, JE; Williams, JR; August, JT; Leong, KW, Immuno-microsphere as gene delivery vehicle: Targeting of LAMP-1 to lysosomal membrane, Proceedings of the Controlled Release Society no. 21 (1994), pp. 142-143 [abs].
  • Lo, H; Kadiyala, S; Guggino, SE; Leong, KW, Biodegradable foams for cell transplantation, Materials Research Society Symposium Proceedings, vol 331 (1994), pp. 41-46 [abs].
  • Brown, KE; Shao, W; Bathon, J; Leong, KW, Controlled drug delivery to the joints by enzymatically degradable microspheres, Materials Research Society Symposium Proceedings, vol 331 (1994), pp. 73-78 [abs].
  • Shao, W; Jaffee, EM; Pardoll, DM; Leong, KW, Delivery of cytokines by microencapsulated transduced cells, Proceedings of the International Symposium on Controlled Release of Bioactive Materials no. 21 (1994), pp. 46-47 [abs].
  • Golumbek, PT; Azhari, R; Jaffee, EM; Levitsky, HI; Lazenby, A; Leong, K; Pardoll, DM, Controlled release, biodegradable cytokine depots: A new approach in cancer vaccine design, Cancer Research, vol 53 no. 24 (1993), pp. 5841-5844 [abs].
  • Dahiyat, BI; Hostin, E; Posadas, EM; Leong, KW, Synthesis and characterization of putrescine-based poly(phosphoester-urethanes)., Journal of biomaterials science. Polymer edition, vol 4 no. 5 (1993), pp. 529-543 [abs].
  • Leong, KW; Truong, VL, P-Glycoprotein-Specific Binding of Immuno-Microspheres to Drug-Resistant Kb-V-1 Cells, Faseb Journal, vol 7 no. 4 (1993), pp. A690-A690 [abs].
  • Jampel, HD; Thibault, D; Leong, KW; Uppal, P; Quigley, HA, Glaucoma filtration surgery in nonhuman primates using taxol and etoposide in polyanhydride carriers, Investigative Ophthalmology and Visual Science, vol 34 no. 11 (1993), pp. 3076-3083 [abs].
  • Reisfeld, B; Blackband, S; Calhoun, V; Grossman, S; Eller, S; Leong, K, The use of magnetic resonance imaging to track controlled drug release and transport in the brain, Magnetic Resonance Imaging, vol 11 no. 2 (1993), pp. 247-252 [abs].
  • Kalyanasundaram, S; Reisfeld, B; Calhoun, VD; Leong, KW, Polymeric controlled release and transport in the brain - A mathematical model, Proceedings of the Controlled Release Society no. 20 (1993), pp. 51-52 [abs].
  • Lee, DA; Jr, LTG; Panek, WC; Leong, KW; Glasgow, BJ, Effects of cytosine arabinoside-impregnated bioerodible polymers on glaucoma filtration surgery in rabbits, Journal of Glaucoma, vol 2 no. 2 (1993), pp. 96-100 [abs].
  • Truong, VL; Leong, KW, A target-specific microspheres drug delivery system made of enzymatically degradable gelatin and chondroitin sulfate coacervates, Proceedings of the Controlled Release Society no. 20 (1993), pp. 474-475 [abs].
  • Heffez, DS; Leong, KW, Sustained release of papaverine for the treatment of cerebral vasospasm: In vitro evaluation of release kinetics and biological activity, Journal of Neurosurgery, vol 77 no. 5 (1992), pp. 783-787 [abs].
  • Krenn, M; Gamcsik, MP; Vogelsang, GB; Colvin, OM; Leong, KW, Improvements in solubility and stability of thalidomide upon complexation with hydroxypropyl-β-cyclodextrin, Journal of Pharmaceutical Sciences, vol 81 no. 7 (1992), pp. 685-689 [10.1002/jps.2600810719] [abs].
  • Dahiyat, B; Shi, F; Zhao, Z; Leong, K, Design of degradable elastomers for medical applications, Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, vol 66 (1992), pp. 87-88 [abs].
  • Dahiyat, BI; Hostin, E; Posadas, EM; Cynamon, MH; Leong, K, Degradable Poly(phosphoester-urethanes) based on putrescine for medical applications, Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, vol 67 (1992), pp. 83-84 [abs].
  • Jampel, HD; Koya, P; Leong, K; Quigley, HA, In vitro release of hydrophobic drugs from polyanhydride disks, Ophthalmic Surgery, vol 22 no. 11 (1991), pp. 676-680 [abs].
  • Saltzman, WM; Parsons-Wingerter, P; Leong, KW; Lin, S, Fibroblast and hepatocyte behavior on synthetic polymer surfaces, Journal of Biomedical Materials Research, vol 25 no. 6 (1991), pp. 741-759 [abs].
  • Richards, M; Dahiyat, BI; Arm, DM; Brown, PR; Leong, KW, Evaluation of polyphosphates and polyphosphonates as degradable biomaterials, Journal of Biomedical Materials Research, vol 25 no. 9 (1991), pp. 1151-1167 [abs].
  • Charles, JB; Jr, RG; Wilson, MR; Lee, DA; Baker, RS; Leong, KW; Glasgow, BJ, Use of bioerodible polymers impregnated with mitomycin in glaucoma filtration surgery in rabbits, Ophthalmology, vol 98 no. 4 (1991), pp. 503-508 [abs].
  • Koya, P; Jampel, H; Quigley, H; Leong, K, Pharmacokinetics of Vp-16 Release from Polyanhydrides after Experimental Filtration Surgery, Investigative Ophthalmology & Visual Science, vol 32 no. 4 (1991), pp. 745-745 [abs].
  • Lewis, H; Schwartz, S; Lee, D; Leong, K, The Use of Bioerodible Polymer and 5-Fluorouracil in the Treatment of Experimental Proliferative Vitreoretinopathy, Investigative Ophthalmology & Visual Science, vol 32 no. 4 (1991), pp. 1047-1047 [abs].
  • Richards, M; Dahiyat, BI; Arm, DM; Lin, S; Leong, KW, Interfacial polycondensation and characterization of polyphosphates and polyphosphonates, Journal of Polymer Science Part A: Polymer Chemistry, vol 29 no. 8 (1991), pp. 1157-1165 [10.1002/pola.1991.080290809] [abs].
  • Tanner, K; Kadiyala, S; Frondoza, C; Leong, K, Effects of biodegradable polymers on macrophage functions in vitro, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium, vol 14 (1991) [abs].
  • Shi, FY; Wang, LF; Leong, KW, Synthesis and characterization of hydrolytically labile polyurethanes, American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol 31 no. 2 (1990) [abs].
  • Tashev, E; Shi, FY; Leong, KW, Potential applications of poly(phosphoester-urethanes) in controlled drug delivery, Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, vol 63 (1990), pp. 43-46 [abs].
  • Leong, KW, Poly(phosphoesters) as biomaterials, American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol 31 no. 1 (1990) [abs].
  • Jampel, HD; Leong, KW; Dunkelburger, GR; Quigley, HA, Glaucoma filtration surgery in monkeys using 5-fluorouridine in polyanhydride disks, Archives of Ophthalmology, vol 108 no. 3 (1990), pp. 430-435 [abs].
  • Tamargo, RJ; Leong, KW; Brem, H, Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate, Journal of Neuro-Oncology, vol 9 no. 2 (1990), pp. 131-138 [10.1007/BF02427833] [abs].
  • Wong, NC; Leong, KW; Shapiro, JH, Nonclassical intensity correlation from a type I phase matched optical parametric oscillator, XVII International Conference on Quantum Electronics. Digest of (1990), pp. 68-70 [abs].
  • Brem, H; Kader, A; Epstein, JI; Tamargo, RJ; Domb, A; Langer, R; Leong, KW, Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain, Selective Cancer Therapeutics, vol 5 no. 2 (1989), pp. 55-65 [abs].
  • Kost, J; Leong, K; Langer, R, Ultrasound-Enhanced Polymer Degradation and Release of Incorporated Substances - (Controlled Release Drug Delivery Systems), Proceedings of the National Academy of Sciences of the United States of America, vol 86 no. 20 (1989), pp. 7663-7666 [abs].
  • Li, NH; Richards, M; Brandt, K; Leong, K, Poly(phosphate esters) as drug-carriers, American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol 30 no. 1 (1989), pp. 454-455 [abs].
  • Kost, J; Leong, K; Langer, R, Ultrasound-enhanced polymer degradation and release of incorporated substances., Proceedings of the National Academy of Sciences of the United States of America, vol 86 no. 20 (1989), pp. 7663-7666 [abs].
  • Bindschaedler, C; Leong, K; Mathiowitz, E; Langer, R, Polyanhydride microsphere formulation by solvent extraction, Journal of Pharmaceutical Sciences, vol 77 no. 8 (1988), pp. 696-698 [abs].
  • Lee, DA; Leong, KW; Panek, WC; Eng, CT; Glasgow, BJ, The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery, Investigative Ophthalmology and Visual Science, vol 29 no. 11 (1988), pp. 1692-1697 [abs].
  • Leong, KW; Langer, R, Polymeric controlled drug delivery, Advanced Drug Delivery Reviews, vol 1 no. 3 (1988), pp. 199-233 [abs].
  • Lee, DA; Flores, RA; Anderson, PJ; Leong, KW; Teekhasaenee, C; Kater, AWD; Hertzmark, E, Glaucoma filtration surgery in rabbits using bioerodible polymers and 5-fluorouracil, Ophthalmology, vol 94 no. 12 (1987), pp. 1523-1530 [abs].
  • Leong, KW; Simonte, V; Langer, R, Synthesis of polyanhydrides: Melt-polycondensation, dehydrochlorination, and dehydrative coupling, Macromolecules, vol 20 no. 4 (1987), pp. 705-712 [abs].
  • Leong, KW; D'Amore, P; Marletta, M; Langer, R, Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity, Journal of Biomedical Materials Research, vol 20 no. 1 (1986), pp. 51-64 [abs].
  • Leong, KW; Kost, J; Mathiowitz, E; Langer, R, Polyanhydrides for controlled release of bioactive agents, Biomaterials, vol 7 no. 5 (1986), pp. 364-371 [10.1016/0142-9612(86)90007-4] [abs].
  • Langer, R; Siegel, R; Brown, L; Leong, K; Kost, J; Edelman, E, CONTROLLED RELEASE: THREE MECHANISMS., CHEMTECH, vol 16 no. 2 (1986), pp. 108-110 [abs].
  • Leong, KW; Brott, BC; Langer, R, Bioerodible polyanhydrides as drug-carrier matrices. I: Characterization, degradation, and release characteristics, Journal of Biomedical Materials Research, vol 19 no. 8 (1985), pp. 941-955 [abs].
  • Langer, R; Siegel, R; Brown, L; Leong, K; Kost, J; Edelman, E, Controlled Release and Magnetically Modulated Systems for Macromolecular Drugs, Annals of the New York Academy of Sciences, vol 446 (1985), pp. 1-13 [abs].
  • Langer, R; Lund, D; Leong, K; Folkman, J, Controlled release of macromolecules: Biological studies, Journal of Controlled Release, vol 2 no. C (1985), pp. 331-341 [abs].
  • Leong, KW; Brott, BC; Langer, R, BIOERODIBLE POLYANHYDRIDES AS A DRUG CARRIER MATRIX., American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol 25 no. 1 (1984), pp. 201-202 [abs].
  • Leong, K; Forsman, WC; Vogel, FL, Conversion of carbon-graphite fibers to fibers of graphite oxide, Materials Science and Engineering, vol 64 no. 2 (1984), pp. 149-155 [abs].
  • Langer, R; Siegel, R; Brown, L; Leong, K; Kost, J; Edelman, E, CONTROLLED RELEASE SYSTEMS: SOME RECENT ADVANCES., Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Material, vol 51 (1984), pp. 115-118 [abs].
  • Leong, K; Forsman, WC; Vogel, FL, Conversion of carbon/graphite fibres to fibres of graphite oxide (1984) [abs].
  • Leong, K; Forsman, WC, Electron-Transfer to Protons in Graphite-Intercalation, Synthetic Metals, vol 6 no. 1 (1983), pp. 61-63 [abs].
  • Leong, K; Tome, A; Dziemianowicz, T; Forsman, W, Intercalation of transition metal dichlorides with no as coreagent (abstract), Synthetic Metals, vol 7 no. 1-2 (1983) [abs].
  • Forsman, WC; Dziemianowicz, T; Leong, K; Carl, D, Graphite intercalation chemistry: An interpretive review, Synthetic Metals, vol 5 no. 2 (1983), pp. 77-100 [abs].
  • Leong, K; Forsman, WC, Electron transfer to protons in graphite intercalation, Synthetic Metals, vol 6 no. C (1983), pp. 61-63 [abs].
  • Dziemianowicz, T; Leong, K; Forsman, WC, INTERCALATION-DESORPTION STUDIES OF GRAPHITE NITRATE., Materials Research Society Symposia Proceedings, vol 20 (1983), pp. 277-282 [abs].
  • Leong, K; Forsman, WC; Vogel, FL, Intercalation of Graphite with the Adducts of Nitrosyl Chloride and Metal Chlorides, Carbon, vol 20 no. 2 (1982), pp. 135-135 [abs].
  • Leong, K; Forsman, WC, Vapor-Phase Intercalation by Alcl3-Hcl Mixtures, Carbon, vol 20 no. 2 (1982), pp. 132-132 [abs].