David Needham

Publications

  • Manzoor, AA; Lindner, LH; Landon, CD; Park, JY; Simnick, AJ; Dreher, MR; Das, S; Hanna, G; Park, W; Chilkoti, A; Koning, GA; ten Hagen, TL; Needham, D; Dewhirst, MW, Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors., Cancer Research, vol 72 no. 21 (2012), pp. 5566-5575 [10.1158/0008-5472.CAN-12-1683] [abs].
  • Gilchrist, SE; Rickard, DL; Letchford, K; Needham, D; Burt, HM, Phase separation behavior of fusidic acid and rifampicin in PLGA microspheres, Molecular Pharmaceutics, vol 9 no. 5 (2012), pp. 1489-1501 [10.1021/mp300099f] [abs].
  • Needham, D, Lipid structures: a brief history of multisomes., Nature Nanotechnology, vol 6 no. 12 (2011), pp. 761-762 [10.1038/nnano.2011.218] [abs].
  • Landon, CD; Park, JY; Needham, D; Dewhirst, MW, Nanoscale drug delivery and hyperthermia: The materials design and preclinical and clinical testing of low temperature-sensitive liposomes used in combination with mild hyperthermia in the treatment of local cancer, Open Nanomedicine Journal, vol 3 no. SPEC. ISSUE (2011), pp. 38-64 [abs].
  • Rickard, DL; Duncan, PB; Needham, D, Hydration potential of lysozyme: protein dehydration using a single microparticle technique., Biophysical Journal, vol 98 no. 6 (2010), pp. 1075-1084 [10.1016/j.bpj.2009.11.043] [abs].
  • Su, JT; Duncan, PB; Momaya, A; Jutila, A; Needham, D, The effect of hydrogen bonding on the diffusion of water in n-alkanes and n-alcohols measured with a novel single microdroplet method., Journal of Chemical Physics, vol 132 no. 4 (2010) [10.1063/1.3298857] [abs].
  • Yarmolenko, PS; Zhao, Y; Landon, C; Spasojevic, I; Yuan, F; Needham, D; Viglianti, BL; Dewhirst, MW, Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours., International Journal of Hyperthermia, vol 26 no. 5 (2010), pp. 485-498 [10.3109/02656731003789284] [abs].
  • Yang, C; Plackett, D; Needham, D; Burt, HM, PLGA and PHBV microsphere formulations and solid-state characterization: Possible implications for local delivery of fusidic acid for the treatment and prevention of orthopaedic infections, Pharmaceutical Research, vol 26 no. 7 (2009), pp. 1644-1656 [10.1007/s11095-009-9875-5] [abs].
  • Chen, Q; Krol, A; Wright, A; Needham, D; Dewhirst, MW; Yuan, F, Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome., International Journal of Hyperthermia, vol 24 no. 6 (2008), pp. 475-482 [10.1080/02656730701854767] [abs].
  • Tashjian, JA; Dewhirst, MW; Needham, D; Viglianti, BL, Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques., International Journal of Hyperthermia, vol 24 no. 1 (2008), pp. 79-90 [10.1080/02656730701840147] [abs].
  • Montalvo-Ortiz, BL; Sosa, B; Velez, D; Needham, D; Griebenow, K, Novel encapsulation of partially dehydrated protein microparticles in PLGA microspheres, Journal of Biotechnology, vol 131 no. 2 (2007), pp. S51-S52 [10.1016/j.jbiotec.2007.07.084] [abs].
  • Holden, MA; Needham, D; Bayley, H, Functional bionetworks from nanoliter water droplets, Journal of the American Chemical Society, vol 129 no. 27 (2007), pp. 8650-8655 [10.1021/ja072292a] [abs].
  • Simon, SI; Nyunt, T; Florine-Casteel, K; Ritchie, K; Ting-Beall, HP; Evans, E; Needham, D, Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer, Annals of Biomedical Engineering, vol 35 no. 4 (2007), pp. 595-604 [10.1007/s10439-007-9260-7] [abs].
  • Hauck, ML; LaRue, SM; Petros, WP; Poulson, JM; Yu, D; Spasojevic, I; Pruitt, AF; Klein, A; Case, B; Thrall, DE; Needham, D; Dewhirst, MW, Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors., Clinical Cancer Research, vol 12 no. 13 (2006), pp. 4004-4010 [10.1158/1078-0432.CCR-06-0226] [abs].
  • Ponce, AM; Vujaskovic, Z; Yuan, F; Needham, D; Dewhirst, MW, Hyperthermia mediated liposomal drug delivery., International Journal of Hyperthermia, vol 22 no. 3 (2006), pp. 205-213 [10.1080/02656730600582956] [abs].
  • Duncan, PB; Needham, D, Microdroplet dissolution into a second-phase solvent using a micropipet technique: test of the Epstein-Plesset model for an aniline-water system., Langmuir: the ACS journal of surfaces and colloids, vol 22 no. 9 (2006), pp. 4190-4197 [10.1021/la053314e] [abs].
  • Ponce, AM; Wright, A; Dewhirts, MW; Needham, D, Targeted bioavailability of drugs by triggered release from liposomes, Clinical Lipidology, vol 1 no. 1 (2006), pp. 25-34 [10.2217/17460875.1.1.25] [abs].
  • Wei, C; Lyubchenko, YL; Ghandehari, H; Hanes, J; Stebe, KJ; Mao, HQ; Haynie, DT; Tomalia, DA; Foldvari, M; Monteiro-Riviere, N; al, E, New technology and clinical applications of nanomedicine: Highlights of the second annual meeting of the American Academy of Nanomedicine (Part I), Nanomedicine: Nanotechnology, Biology and Medicine, vol 2 no. 4 (2006), pp. 253-263 [10.1016/j.nano.2006.11.001] [abs].
  • Mills, JK; Needham, D, Temperature-triggered nanotechnology for chemotherapy: Rapid release from lysolipid temperature-sensitive liposomes, 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings, vol 2 (2006), pp. 5-8 [abs].
  • Mills, JK; Needham, D, Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition., Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, vol 1716 no. 2 (2005), pp. 77-96 [10.1016/j.bbamem.2005.08.007] [abs].
  • Needham, DJ; Leach, JA; Merkin, JH, The effects of a complexation reaction on travelling wave-fronts in a quadratic autocatalytic system, Q. J. Mech. Appl. Math. (UK), vol 58 (2005), pp. 577-599 [10.1093/qjmam/hbi022] [abs].
  • Merkin, JH; Needham, DJ; Sleeman, BD, A mathematical model for the spread of morphogens with density dependent chemosensitivity, Nonlinearity (UK), vol 18 no. 6 (2005), pp. 2745-2773 [10.1088/0951-7715/18/6/018] [abs].
  • Eichenbaum, KD; Thomas, AA; Eichenbaum, GM; Gibney, BR; Needham, D; Kiser, PF, Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks, Macromolecules, vol 38 no. 26 (2005), pp. 10757-10762 [10.1021/ma0518306] [abs].
  • Duncan, PB; Needham, D, Test of the Epstein-Plesset model for gas microparticle dissolution in aqueous media: effect of surface tension and gas undersaturation in solution., Langmuir: the ACS journal of surfaces and colloids, vol 20 no. 7 (2004), pp. 2567-2578 [abs].
  • Mills, JK; Needham, D, The materials engineering of temperature-sensitive liposomes., Methods in Enzymology, vol 387 (2004), pp. 82-113 [10.1016/S0076-6879(04)87006-X] [abs].
  • Ickenstein, LM; Arfvidsson, MC; Needham, D; Mayer, LD; Edwards, K, Disc formation in cholesterol-free liposomes during phase transition, Biochimica et Biophysica Acta - Biomembranes, vol 1614 no. 2 (2003), pp. 135-138 [10.1016/S0005-2736(03)00196-2] [abs].
  • Needham, D, Lipid Membranes: Biological Inspiration for Micro and Nano Encapsulation Technologies, Especially Drug Delivery, Materials Research Society Symposium - Proceedings, vol 774 (2003), pp. 173-202 [abs].
  • Kim, DH; Costello, MJ; Duncan, PB; Needham, D, Mechanical properties and microstructure of polycrystalline phospholipid monolayer shells: Novel solid microparticles, Langmuir, vol 19 no. 20 (2003), pp. 8455-8466 [10.1021/la034779c] [abs].
  • Hasik, MJ; Kim, DH; Howle, LE; Needham, D; Prush, DP, Evaluation of synthetic phospholipid ultrasound contrast agents., Ultrasonics, vol 40 no. 9 (2002), pp. 973-982 [abs].
  • Zhelev, DV; Needham, D, Interactions of pH-sensitive peptides and polymers with lipid bilayers: Binding and membrane stability, Current Topics in Membranes, vol 52 (2002), pp. 437-464 [abs].
  • Needham, D; Dewhirst, MW, The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors., Advanced Drug Delivery Reviews, vol 53 no. 3 (2001), pp. 285-305 [abs].
  • Zhelev, DV; Stoicheva, N; Scherrer, P; Needham, D, Interaction of synthetic HA2 influenza fusion peptide analog with model membranes., Biophysical Journal, vol 81 no. 1 (2001), pp. 285-304 [10.1016/S0006-3495(01)75699-8] [abs].
  • Eichenbaum, GM; Kiser, PF; Simon, SA; Needham, D, Erratum: pH and ion-triggered volume responses of anionic hydrogel microspheres (Macromolecules (July 28, 1998) 31:15 (5084-5093)), Macromolecules, vol 34 no. 20 (2001) [10.1021/ma012488] [abs].
  • Eichenbaum, GM; Kiser, PF; Dobrynin, AV; Simon, SA; Needham, D, Erratum: Investigation of the swelling response and loading of ionic microgels with drugs and proteins; The dependence on cross-link density (Macromolecules (July 27, 1999) 32:15 (4867-4878)), Macromolecules, vol 34 no. 18 (2001) [10.1021/ma0124892] [abs].
  • Lee, S; Kim, DH; Needham, D, Equilibrium and dynamic interfacial tension measurements at microscopic interfaces using a micropipet technique - 2. Dynamics of phospholipid monolayer formation and equilibrium tensions at the water-air interface, Langmuir: the ACS journal of surfaces and colloids, vol 17 no. 18 (2001), pp. 5544-5550 [10.1021/la0103261] [abs].
  • Lee, S; Kim, DH; Needham, D, Equilibrium and Dynamic Interfacial Tension Measurements at Microscopic Interfaces Using a Micropipet Technique. 1. A New Method for Determination of Interfacial Tension, Langmuir: the ACS journal of surfaces and colloids, vol 17 no. 18 (2001), pp. 5537-5543 [10.1021/la0103259] [abs].
  • Kong, G; Anyarambhatla, G; Petros, WP; Braun, RD; Colvin, OM; Needham, D; Dewhirst, MW, Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release., Cancer Research, vol 60 no. 24 (2000), pp. 6950-6957 [abs].
  • Needham, D; Kim, DH, PEG-covered lipid surfaces: bilayers and monolayers., Colloids and Surfaces B: Biointerfaces, vol 18 no. 3-4 (2000), pp. 183-195 [abs].
  • Matteucci, ML; Anyarambhatla, G; Rosner, G; Azuma, C; Fisher, PE; Dewhirst, MW; Needham, D; Thrall, DE, Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas., Clinical Cancer Research, vol 6 no. 9 (2000), pp. 3748-3755 [abs].
  • Olbrich, K; Rawicz, W; Needham, D; Evans, E, Water permeability and mechanical strength of polyunsaturated lipid bilayers., Biophysical Journal, vol 79 no. 1 (2000), pp. 321-327 [10.1016/S0006-3495(00)76294-1] [abs].
  • Needham, D; Anyarambhatla, G; Kong, G; Dewhirst, MW, A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model., Cancer Research, vol 60 no. 5 (2000), pp. 1197-1201 [abs].
  • Kiser, PF; Thomas, AA; Eichenbaum, GM; Needham, D; Kim, I, Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters, American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol 41 no. 1 (2000), pp. 712-713 [abs].
  • Needham, D; Demurjian, S; Peters, T, An IDL to Ada95 mapping to support propagation modeling, Ada Lett. (USA), vol 20 no. 1 (2000), pp. 58-66 [abs].
  • Howell, ML; Alsabbagh, E; Ma, JF; Ochsner, UA; Klotz, MG; Beveridge, TJ; Blumenthal, KM; Niederhoffer, EC; Morris, RE; Needham, D; al, E, AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide, Journal of Bacteriology, vol 182 no. 16 (2000), pp. 4545-4556 [10.1128/JB.182.16.4545-4556.2000] [abs].
  • Rawicz, W; Olbrich, KC; McIntosh, T; Needham, D; Evans, EA, Effect of chain length and unsaturation on elasticity of lipid bilayers, Biophysical Journal, vol 79 no. 1 (2000), pp. 328-339 [abs].
  • Kim, DH; Klibanov, AL; Needham, D, The influence of tiered layers of surface-grafted poly(ethylene glycol) on receptor-ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated glass beads, Langmuir: the ACS journal of surfaces and colloids, vol 16 no. 6 (2000), pp. 2808-2817 [abs].
  • Eichenbaum, GM; Kiser, PF; Shah, D; Meuer, WP; Needham, D; Simon, SA, Alkali earth metal binding properties of ionic microgels, Macromolecules, vol 33 no. 11 (2000), pp. 4087-4093 [10.1021/ma9917139] [abs].
  • Kiser, PF; Wilson, G; Needham, D, Lipid-coated microgels for the triggered release of doxorubicin, Journal of Controlled Release, vol 68 no. 1 (2000), pp. 9-22 [10.1016/S0168-3659(00)00236-4] [abs].
  • Needham, D, Materials engineering of lipid bilayers for drug carrier performance, MRS Bulletin, vol 24 no. 10 (1999), pp. 32-40 [abs].
  • Klibanov, AL; Gu, H; Wojdyla, JK; Jr, WJH; Kim, DH; Needham, D; Villanueva, FS; Brandenburger, GH, Attachment of ligands to gas-filled microbubbles via PEG spacer and lipid residues anchored at the interface, Proceedings of the Controlled Release Society no. 26 (1999), pp. 124-125 [abs].
  • Eichenbaum, GM; Kiser, PF; Dobrynin, AV; Simon, SA; Needham, D, Investigation of the swelling response and loading of ionic microgels with drugs and proteins: the dependence on cross-link density, Macromolecules, vol 32 no. 15 (1999), pp. 4867-4878 [10.1021/ma981945s] [abs].
  • Eichenbaum, GM; Kiser, PF; Shah, D; Simon, SA; Needham, D, Investigation of the swelling response and drug loading of ionic microgels: The dependence on functional group composition, Macromolecules, vol 32 no. 26 (1999), pp. 8996-9006 [10.1021/ma9908393] [abs].
  • Mills, JK; Eichenbaum, G; Needham, D, Effect of bilayer cholesterol and surface grafted poly(ethylene glycol) on pH-induced release of contents from liposomes by poly(2-ethylacrylic acid), Journal of Liposome Research, vol 9 no. 2 (1999), pp. 275-290 [abs].
  • Anyarambhatla, GR; Needham, D, Enhancement of the phase transition permeability of DPPC liposomes by incorporation of MPPC: A new temperature-sensitive liposome for use with mild hyperthermia, Journal of Liposome Research, vol 9 no. 4 (1999), pp. 491-506 [abs].
  • Mills, JK; Needham, D, Targeted drug delivery, Expert Opinion on Therapeutic Patents, vol 9 no. 11 (1999), pp. 1499-1513 [10.1517/13543776.9.11.1499] [abs].
  • Kiser, PF; Wilson, G; Needham, D, A synthetic mimic of the secretory granule for drug delivery., Nature, vol 394 no. 6692 (1998), pp. 459-462 [10.1038/28822] [abs].
  • Eichenbaum, GM; Kiser, PF; Simon, SA; Needham, D, pH and Ion-Triggered Volume Response of Anionic Hydrogel Microspheres., Macromolecules, vol 31 no. 15 (1998), pp. 5084-5093 [10.1021/ma970897t] [abs].
  • Needham, DJ; McAllister, S, Centre families in two-dimensional complex holomorphic dynamical systems, Proc. R. Soc. Lond. A, Math. Phys. Eng. Sci. (UK), vol 454 no. 1976 (1998), pp. 2267-2278 [10.1098/rspa.1998.0258] [abs].
  • Needham, D; McIntosh, TJ; Simon, SA; Zhelev, D, Adsorption, molecular exchange and defect formation in membranes, Current Opinion in Colloid and Interface Science, vol 3 no. 5 (1998), pp. 511-517 [abs].
  • Needham, D; Mills, J; Eichenbaum, G, Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol)., Faraday Discussions no. 111 (1998), pp. 103-110 [abs].
  • Needham, D; Sarpal, RS, Binding of paclitaxel to lipid interfaces: Correlations with interface compliance, Journal of Liposome Research, vol 8 no. 2 (1998), pp. 147-163 [abs].
  • Needham, D; Stoicheva, N; Zhelev, DV, Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid., Biophysical Journal, vol 73 no. 5 (1997), pp. 2615-2629 [10.1016/S0006-3495(97)78291-2] [abs].
  • Kiser, PF; Needham, D; Wilson, G, Mimicking the smart polymer matrix of the secretory granule: a new concept in controlled release drug delivery, Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, vol 76 (1997) [abs].
  • Needham, D; Noppl-Simson, D, Barrier properties of surface-grafted PEG for macromolecule-surface interactions, American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol 38 no. 1 (1997), pp. 549-550 [abs].
  • Noppl-Simson, DA; Needham, D, Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions., Biophysical Journal, vol 70 no. 3 (1996), pp. 1391-1401 [10.1016/S0006-3495(96)79697-2] [abs].
  • Bowman, H; Evans, E; Needham, D; Tirrell, DA, Nanometer-scale polymeric patterns and networks, Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, vol 74 (1996) [abs].
  • Zhelev, DV; Needham, D, Pore formation and pore dynamics in bilayer membranes, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol 34 (1996), pp. 47-49 [abs].
  • Needham, DJ; King, AC; Merkin, JH, Reaction-diffusion model for autocatalytic polymerization: II. The initial value problem, IMA Journal of Applied Mathematics (Institute of Mathematics & Its Applications), vol 56 no. 1 (1996), pp. 65-86 [abs].
  • Evans, E; Bowman, H; Leung, A; Needham, D; Tirrell, D, Biomembrane templates for nanoscale conduits and networks, Science, vol 273 no. 5277 (1996), pp. 933-935 [abs].
  • McIntosh, TJ; Advani, S; Burton, RE; Zhelev, DV; Needham, D; Simon, SA, Experimental tests for protrusion and undulation pressures in phospholipid bilayers., Biochemistry, vol 34 no. 27 (1995), pp. 8520-8532 [abs].
  • Needham, D; Zhelev, DV, Lysolipid exchange with lipid vesicle membranes., Annals of Biomedical Engineering, vol 23 no. 3 (1995), pp. 287-298 [abs].
  • Kenworthy, AK; Hristova, K; Needham, D; McIntosh, TJ, Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol)., Biophysical Journal, vol 68 no. 5 (1995), pp. 1921-1936 [10.1016/S0006-3495(95)80369-3] [abs].
  • HRISTOVA, K; NEEDHAM, D, INFLUENCE OF BILAYER FLUCTUATIONS ON THE STERIC INTERACTIONS BETWEEN POLYMER-GRAFTED BILAYERS, Liquid Crystals, vol 18 no. 3 (1995), pp. 423-430 [10.1080/02678299508036641] [abs].
  • Needham, DJ, Centre theorem for two-dimensional complex holomorphic systems and its generalization, Proceedings of The Royal Society of London, Series A: Mathematical and Physical Sciences, vol 450 no. 1939 (1995), pp. 225-232 [abs].
  • Needham, D; Zhelev, DV, Lysolipid exchange with vesicle membranes and the formation and evolution of porous defects, Annals of Biomedical Engineering, vol 23 no. 3 (1995) [abs].
  • Needham, D; Noppl, D, Adsorption and adhesion at vesicle surfaces: the influence of grafted polymer on avidin-biotin binding and tests of receptor-mediated adhesion, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol 29 (1995), pp. 331-332 [abs].
  • Hristova, K; Needham, D, Phase behavior of a lipid/polymer-lipid mixture in aqueous medium, Macromolecules, vol 28 no. 4 (1995), pp. 991-1002 [abs].
  • Lasic, DD; Needham, D, The "Stealth" liposome: A prototypical biomaterial, Chemical Reviews, vol 95 no. 8 (1995), pp. 2601-2628 [abs].
  • Zhelev, DV; Needham, D; Hochmuth, RM, A novel micropipet method for measuring the bending modulus of vesicle membranes., Biophysical Journal, vol 67 no. 2 (1994), pp. 720-727 [10.1016/S0006-3495(94)80530-2] [abs].
  • Zhelev, DV; Needham, D; Hochmuth, RM, Role of the membrane cortex in neutrophil deformation in small pipets., Biophysical Journal, vol 67 no. 2 (1994), pp. 696-705 [10.1016/S0006-3495(94)80529-6] [abs].
  • Simon, SA; Disalvo, EA; Gawrisch, K; Borovyagin, V; Toone, E; Schiffman, SS; Needham, D; McIntosh, TJ, Increased adhesion between neutral lipid bilayers: interbilayer bridges formed by tannic acid., Biophysical Journal, vol 66 no. 6 (1994), pp. 1943-1958 [10.1016/S0006-3495(94)80988-9] [abs].
  • Hristova, K; Needham, D, The Influence of Polymer-Grafted Lipids on the Physical Properties of Lipid Bilayers: A Theoretical Study, Journal of Colloid and Interface Science, vol 168 no. 2 (1994), pp. 302-314 [10.1006/jcis.1994.1424] [abs].
  • Wu, NZ; Klitzman, B; Rosner, G; Needham, D; Dewhirst, MW, Measurement of material extravasation in microvascular networks using fluorescence video-microscopy., Microvascular Research, vol 46 no. 2 (1993), pp. 231-253 [10.1006/mvre.1993.1049] [abs].
  • Wu, NZ; Da, D; Rudoll, TL; Needham, D; Whorton, AR; Dewhirst, MW, Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue., Cancer Research, vol 53 no. 16 (1993), pp. 3765-3770 [abs].
  • Ting-Beall, HP; Needham, D; Hochmuth, RM, Volume and osmotic properties of human neutrophils., Blood, vol 81 no. 10 (1993), pp. 2774-2780 [abs].
  • Hochmuth, RM; Ting-Beall, HP; Beaty, BB; Needham, D; Tran-Son-Tay, R, Viscosity of passive human neutrophils undergoing small deformations., Biophysical Journal, vol 64 no. 5 (1993), pp. 1596-1601 [10.1016/S0006-3495(93)81530-3] [abs].
  • Zhelev, DV; Needham, D, Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension., Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, vol 1147 no. 1 (1993), pp. 89-104 [abs].
  • Kavanagh, BD; Coffey, BE; Needham, D; Hochmuth, RM; Dewhirst, MW, The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment., British Journal of Cancer, vol 67 no. 4 (1993), pp. 734-741 [abs].
  • Needham, D, Measurement of interbilayer adhesion energies., Methods in Enzymology, vol 220 (1993), pp. 111-129 [abs].
  • Sonkin, PL; Freedman, SF; Needham, D; Rao, KM; Hatchell, DL, Pentoxifylline modulates deformability, F-actin content, and superoxide anion production of polymorphonuclear leukocytes from diabetic cats., Experimental Eye Research, vol 55 no. 6 (1992), pp. 831-838 [abs].
  • Needham, D; McIntosh, TJ; Lasic, DD, Repulsive interactions and mechanical stability of polymer-grafted lipid membranes., Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, vol 1108 no. 1 (1992), pp. 40-48 [abs].
  • Needham, D; Hochmuth, RM, A sensitive measure of surface stress in the resting neutrophil., Biophysical Journal, vol 61 no. 6 (1992), pp. 1664-1670 [10.1016/S0006-3495(92)81970-7] [abs].
  • Simon, SA; McIntosh, TJ; Magid, AD; Needham, D, Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface., Biophysical Journal, vol 61 no. 3 (1992), pp. 786-799 [10.1016/S0006-3495(92)81883-0] [abs].
  • McIntosh, TJ; Simon, SA; Needham, D; Huang, CH, Structure and cohesive properties of sphingomyelin/cholesterol bilayers., Biochemistry, vol 31 no. 7 (1992), pp. 2012-2020 [abs].
  • McIntosh, TJ; Simon, SA; Needham, D; Huang, CH, Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers., Biochemistry, vol 31 no. 7 (1992), pp. 2020-2024 [abs].
  • Needham, DJ, Formal theory concerning the generation and propagation of travelling wave-fronts in reaction-diffusion equations, Quarterly Journal of Mechanics and Applied Mathematics, vol 45 no. pt 3 (1992), pp. 469-498 [abs].
  • Needham, D; Hristova, K; McIntosh, TJ; Dewhirst, M; Wu, N; Lasic, DD; Alving, CR; Wassef, NM; Senior, JH; Ghosh, PC; Bachhawat, BK; Allen, TM, Polymer-grafted liposomes: Physical basis for the 'Stealth' property, Journal of Liposome Research, vol 2 no. 3 (1992), pp. 411-430 [abs].
  • Needham, D; Ting-Beall, HP; Tran-Son-Tay, R, A physical characterization of GAP A3 hybridoma cells: morphology, geometry, and mechanical properties., Biotechnology and Bioengineering, vol 38 no. 8 (1991), pp. 838-852 [10.1002/bit.260380806] [abs].
  • Tran-Son-Tay, R; Needham, D; Yeung, A; Hochmuth, RM, Time-dependent recovery of passive neutrophils after large deformation., Biophysical Journal, vol 60 no. 4 (1991), pp. 856-866 [10.1016/S0006-3495(91)82119-1] [abs].
  • Needham, D, Possible role of cell cycle-dependent morphology, geometry, and mechanical properties in tumor cell metastasis., Cell Biophysics, vol 18 no. 2 (1991), pp. 99-121 [abs].
  • Needham, D, Morphology, geometry and mechanical properties of GAP A3 hybridoma cells as a function of the cell cycle, Annals of Biomedical Engineering, vol 19 no. 5 (1991), pp. 592-593 [abs].
  • Needham, D; McIntosh, TJ, Mechanical and interactive properties of lipid membranes containing surface-bound polymer, Annals of Biomedical Engineering, vol 19 no. 5 (1991) [abs].
  • Hochmuth, RM; Needham, D; Ting-Beall, HP, Deformation and flow of neutrophils and monocytes, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol 20 (1991), pp. 417-419 [abs].
  • Tran-Son-Tay, R; Needham, D; Hochmuth, RM, Recovery of passive neutrophils after large deformation. Liquid drop model, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol 20 (1991), pp. 421-424 [abs].
  • Hochmuth, RM; Needham, D; Ting-Beall, HP; Zhelev, D, Deformation and flow of neutrophils in micropipets, Annals of Biomedical Engineering, vol 19 no. 5 (1991) [abs].
  • Needham, D; Nunn, RS, Elastic deformation and failure of lipid bilayer membranes containing cholesterol., Biophysical Journal, vol 58 no. 4 (1990), pp. 997-1009 [10.1016/S0006-3495(90)82444-9] [abs].
  • Needham, D; Hochmuth, RM, Rapid flow of passive neutrophils into a 4 microns pipet and measurement of cytoplasmic viscosity., Journal of Biomechanical Engineering, vol 112 no. 3 (1990), pp. 269-276 [abs].
  • Armstrong, M; Needham, D; Hatchell, DL; Nunn, RS, Effect of pentoxifylline on the flow of polymorphonuclear leukocytes through a model capillary., Angiology, vol 41 no. 4 (1990), pp. 253-262 [abs].
  • Needham, D; Ting-Beall, HP; Tran-Son-Tay, R, Morphology and mechanical properties of gap A3 hybridoma cells as related to cell cycle, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol 16 (1990), pp. 5-10 [abs].
  • Hochmuth, RM; Needham, D, The viscosity of neutrophils and their transit times through small pores., Biorheology: an international journal, vol 27 no. 6 (1990), pp. 817-828 [abs].
  • Needham, D; Armstrong, M; Hatchell, DL; Nunn, RS, Rapid deformation of "passive" polymorphonuclear leukocytes: the effects of pentoxifylline., Journal of Cellular Physiology, vol 140 no. 3 (1989), pp. 549-557 [10.1002/jcp.1041400321] [abs].
  • Needham, D; Hochmuth, RM, Electro-mechanical permeabilization of lipid vesicles. Role of membrane tension and compressibility., Biophysical Journal, vol 55 no. 5 (1989), pp. 1001-1009 [10.1016/S0006-3495(89)82898-X] [abs].
  • Needham, D; McIntosh, TJ; Evans, E, Thermomechanical and transition properties of dimyristoylphosphatidylcholine/cholesterol bilayers., Biochemistry, vol 27 no. 13 (1988), pp. 4668-4673 [abs].
  • Evans, E; Needham, D, ATTRACTION BETWEEN LIPID BILAYER MEMBRANES IN CONCENTRATED SOLUTIONS OF NONADSORBING POLYMERS: COMPARISON OF MEAN-FIELD THEORY WITH MEASUREMENTS OF ADHESION ENERGY., Macromolecules, vol 21 no. 6 (1988), pp. 1822-1831 [abs].
  • Needham, D; Evans, E, Structure and mechanical properties of giant lipid (DMPC) vesicle bilayers from 20 °C below to 10 °C above the liquid crystal-crystalline phase transition at 24 °C, Biochemistry, vol 27 no. 21 (1988), pp. 8261-8269 [abs].
  • Evans, E; Needham, D, Physical properties of surfactant bilayer membranes: Thermal transitions, elasticity, rigidity, cohesion, and colloidal interactions, Journal of Physical Chemistry, vol 91 no. 16 (1987), pp. 4219-4228 [abs].
  • Evans, E; Needham, D, Giant vesicle bilayers composed of mixtures of lipids, cholesterol and polypeptides: Thermomechanical and (mutual) adherence properties, Faraday Discussions of the Chemical Society, vol 81 (1986), pp. 267-280 [10.1039/DC9868100267] [abs].
  • Elliott, JR; Haydon, DA; Hendry, BM; Needham, D, Inactivation of the sodium current in squid giant axons by hydrocarbons, Biophysical Journal, vol 48 no. 4 (1985), pp. 617-622 [abs].
  • Elliott, JR; Needham, D; Dilger, JP; Brandt, O; Haydon, DA, A quantitative explanation of the effects of some alcohols on gramicidin single-channel lifetime, BBA: Biomembranes, vol 814 no. 2 (1985), pp. 401-404 [abs].
  • Eley, DD; Needham, D, HYDRIDIZATION AND CATALYSIS BY LANTHANIDE FILMS., Proceedings of The Royal Society of London, Series A: Mathematical and Physical Sciences, vol 393 no. 1805 (1984), pp. 257-276 [abs].
  • Needham, D; Haydon, DA, Tensions and free energies of formation of 'solventless' lipid bilayers. Measurement of high contact angles, Biophysical Journal, vol 41 no. 3 (1983), pp. 251-257 [abs].
  • Elliott, JR; Needham, D; Dilger, JP; Haydon, DA, The effects of bilayer thickness and tension on gramicidin single-channel lifetime, BBA: Biomembranes, vol 735 no. 1 (1983), pp. 95-103 [abs].